{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:11:12Z","timestamp":1787497872173,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T00:00:00Z","timestamp":1469491200000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000615","name":"Fight for Sight UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000615","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Red light has been shown to provide neuroprotective effects. Axotomizing the optic nerve initiates retinal ganglion cell (RGC) degeneration, and an early marker of this is dendritic pruning. We hypothesized that 670\u00a0nm light can delay axotomy\u2010induced dendritic pruning in the retinal explant. To test this hypothesis, we monitored the effects of 670\u00a0nm light (radiant exposure of 31.7\u00a0J\u00a0cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    ), on RGC dendritic pruning in retinal explants from C57BL\/6J mice, at 40\u00a0min, 8\u00a0h and 16\u00a0h post axotomy. For sham\u2010treated retinae, area under the Sholl curve, peak of the Sholl curve and dendritic length at 8\u00a0h post axotomy showed statistically significant reductions by 42.3% (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.008), 29.8% (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.007) and 38.4% (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.038), respectively, which were further reduced after 16\u00a0h by 40.56% (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\n                    <jats:italic>\u00a0<\/jats:italic>\n                    0.008), 33.9% (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\n                    <jats:italic>\u00a0<\/jats:italic>\n                    0.007), 45.43% (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\n                    <jats:italic>\u00a0<\/jats:italic>\n                    0.006), respectively. Dendritic field area was also significantly reduced after 16\u00a0h, by 44.23% (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\n                    <jats:italic>\u00a0<\/jats:italic>\n                    0.019). Such statistically significant reductions were not seen in light\u2010treated RGCs at 8 or 16\u00a0h post axotomy. The results demonstrate the ability of 670\u00a0nm light to partially prevent\n                    <jats:italic>ex\u00a0vivo<\/jats:italic>\n                    dendropathy in the mouse retina, suggesting that it is worth\u00a0exploring as a treatment option for dendropathy\u2010associated\u00a0neurodegenerative diseases, including glaucoma and Alzheimer's disease.\n                  <\/jats:p>","DOI":"10.1111\/php.12606","type":"journal-article","created":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T11:52:50Z","timestamp":1465386770000},"page":"624-631","source":"Crossref","is-referenced-by-count":13,"title":["Red Light Treatment in an Axotomy Model of Neurodegeneration"],"prefix":"10.1111","volume":"92","author":[{"given":"Kathy","family":"Beirne","sequence":"first","affiliation":[{"name":"School of Optometry and Vision Sciences Cardiff University Cardiff UK"},{"name":"Cardiff Institute for Tissue Engineering and Repair Cardiff University Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Rozanowska","sequence":"additional","affiliation":[{"name":"School of Optometry and Vision Sciences Cardiff University Cardiff UK"},{"name":"Cardiff Institute for Tissue Engineering and Repair Cardiff University Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Votruba","sequence":"additional","affiliation":[{"name":"School of Optometry and Vision Sciences Cardiff University Cardiff UK"},{"name":"Cardiff Institute for Tissue Engineering and Repair Cardiff University Cardiff UK"},{"name":"Cardiff Eye Unit University Hospital of Wales Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2011.9908"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140880"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067358"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2012-0086"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20143"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22003"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201400069"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2015.3986"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","unstructured":"Dong T. 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