{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T20:30:17Z","timestamp":1767990617376,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T00:00:00Z","timestamp":1471392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ultraviolet (<jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>) eye irradiation denatures the cells of the intestine. This study examined the action of<jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>on dextran sodium sulfate (<jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>)\u2010induced ulcerative colitis. We produced a mouse model of ulcerative colitis by administering<jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>for 5 days and irradiated the eye with<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>or<jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>for each day of the<jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>treatment period.<jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>\u2010induced ulcerative colitis was deteriorated by the<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>eye irradiation. Conversely, the symptoms improved with<jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>eye irradiation. The levels of adrenocorticotropic hormone (<jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>), corticotropin\u2010releasing hormone (<jats:styled-content style=\"fixed-case\">CRH<\/jats:styled-content>), urocortin 2, interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u201018,<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 and histamine in the blood increased after the<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>eye irradiation of<jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>\u2010treated mice (<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>\u2010treated mice). In contrast, the \u03b2\u2010endorphin level in the blood of the<jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>\u2010treated mice increased and the levels of urocortin 2, tumor necrosis factor (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>)\u2010\u03b1 and histamine decreased. Furthermore, in the colon, the expression of melanocortin\u20102 receptors (<jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>2R) increased in the<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>\u2010treated mice, while the expression of \u03bc\u2010opioid receptors increased in the<jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>\u2010treated mice. When an<jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>inhibitor was administered,<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>eye irradiation caused the deterioration of<jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>\u2010treated ulcerative colitis, while the effect of<jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>eye irradiation disappeared with a \u03bc\u2010opioid receptor antagonist. These results suggested that<jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>eye irradiation plays an important role in<jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>\u2010induced ulcerative colitis.<\/jats:p>","DOI":"10.1111\/php.12620","type":"journal-article","created":{"date-parts":[[2016,7,18]],"date-time":"2016-07-18T16:10:08Z","timestamp":1468858208000},"page":"728-734","source":"Crossref","is-referenced-by-count":20,"title":["The Effects of Ultraviolet Eye Irradiation on Dextran Sodium Sulfate\u2010Induced Ulcerative Colitis in Mice"],"prefix":"10.1111","volume":"92","author":[{"given":"Keiichi","family":"Hiramoto","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Science Suzuka University of Medical Science Suzuka Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yurika","family":"Yamate","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science Suzuka University of Medical Science Suzuka Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eisuke F.","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science Suzuka University of Medical Science Suzuka Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,17]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1419","article-title":"Metagenomic analysis of microbiome in colon tissue from subjects with inflammatory bowel diseases reveals interplay of viruses and bacteria","volume":"21","author":"Wang W.","year":"2015","journal-title":"Inflamm. 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