{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:55:01Z","timestamp":1772160901689,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T00:00:00Z","timestamp":1470960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"JSPS KAKENHI","award":["25870836"],"award-info":[{"award-number":["25870836"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photochem & Photobiology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"Abstract<\/jats:title>\n \n A novel conjugate,\n PHG<\/jats:styled-content>\n 10 dye, was synthesized using a collagen peptide and a near\u2013infrared (\n NIR<\/jats:styled-content>\n )\u2010responsive dye to achieve targeted cytotoxicity. The collagen peptide motif, \u2010(Pro\u2010Hyp\u2010Gly)\n 10<\/jats:sub>\n \u2010 (\n PHG<\/jats:styled-content>\n 10), was incorporated for targeting collagen fibrils that are excessively produced by activated fibroblasts around tumor cells.\n PHG<\/jats:styled-content>\n 10 dye was purified by\n HPLC<\/jats:styled-content>\n and identified by\n MALDI<\/jats:styled-content>\n \u2010\n MS<\/jats:styled-content>\n . The phototoxicity and cytotoxicity of\n PHG<\/jats:styled-content>\n 10 dye were examined using human glioma cells (\n HGC<\/jats:styled-content>\n s). Fluorescent images indicated that\n PHG<\/jats:styled-content>\n 10 dye preferably assembled to collagen\u2010coated\n HGC<\/jats:styled-content>\n s compared with noncoated\n HGC<\/jats:styled-content>\n s. Under irradiation with\n NIR<\/jats:styled-content>\n light, effective cytotoxicity was observed on collagen\u2010coated\n HGC<\/jats:styled-content>\n s within 20 min. Because phototoxicity and cytotoxicity are dependent on the assembled amount of\n PHG<\/jats:styled-content>\n 10 dye, the targeting of collagen fibrils by the collagen peptide motif\n PHG<\/jats:styled-content>\n 10 is assured.\n <\/jats:p>","DOI":"10.1111\/php.12621","type":"journal-article","created":{"date-parts":[[2016,7,18]],"date-time":"2016-07-18T12:17:09Z","timestamp":1468844229000},"page":"767-770","source":"Crossref","is-referenced-by-count":0,"title":["Near\u2013Infrared\u2010Responsive Peptide that Targets Collagen Fibrils to Induce Cytotoxicity"],"prefix":"10.1111","volume":"92","author":[{"given":"Masayuki","family":"Honda","sequence":"first","affiliation":[{"name":"Graduate School of Health Sciences Komazawa University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aoi","family":"Odawara","sequence":"additional","affiliation":[{"name":"Graduate School of Engineering Tohoku Institute of Technology Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Graduate School of Engineering Tohoku Institute of Technology Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morio","family":"Shimada","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences Komazawa University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohki","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences Komazawa University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Okada","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences Komazawa University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,12]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"813","article-title":"Multifunctional, stimuli\u2010sensitive nanoparticulate systems for drug delivery","volume":"13","author":"Torchilin V. 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