{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:16:58Z","timestamp":1790255818577,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,9,23]],"date-time":"2016-09-23T00:00:00Z","timestamp":1474588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Natural Science Foundation of Guangdong Province, China","award":["2014A030313782"],"award-info":[{"award-number":["2014A030313782"]}]},{"name":"Medical Science and Technology Project of Guangzhou, China","award":["2014A011074"],"award-info":[{"award-number":["2014A011074"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ultraviolet B (\n                    <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>\n                    ) irradiation is one of the most dangerous insults for skin and causes sunburn, erythema, photoaging and photocarcinogenesis. Curcumin (diferuloylmethane), a yellow spice derived from dried rhizomes of\n                    <jats:italic>Curcuma longa<\/jats:italic>\n                    , has been shown to possess significant anti\u2010inflammatory, antioxidant, anticarcinogenic, antimutagenic, anticoagulant and anti\u2010infective effects. However, the protective effects of curcumin against acute photo\u2010damage are poorly understood. In this study, we investigated the photoprotective effects of curcumin against\n                    <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>\n                    \u2010induced acute photo\u2010damage in hairless mice and immortalized human keratinocytes (HaCaT). Topical application of curcumin significantly inhibited acute\n                    <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>\n                    (540\n                    <jats:styled-content style=\"fixed-case\">mJ<\/jats:styled-content>\n                    cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    , for 3 successive days)\u2010induced inflammatory cells, collagen accrementition derangement and lipid peroxidation, and effectively induced NF\u2010E2\u2010related factor 2 (Nrf2) nuclear accumulation in uncovered (\n                    <jats:italic>Uncv<\/jats:italic>\n                    ) hairless mice skin. Treatment of HaCaT cells with curcumin significantly attenuated acute\n                    <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>\n                    (300\n                    <jats:styled-content style=\"fixed-case\">mJ<\/jats:styled-content>\n                    cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    )\u2010induced lactate dehydrogenase release, intracellular reactive oxygen species production and\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    damage, activated the expression of the phase\n                    <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n                    detoxifying enzymes and promoted\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    repair activity. The photoprotective effect provided by curcumin was potential associated with modulation of Nrf2\u2010dependent antioxidant response. Our study suggested that curcumin is a potential agent for preventing and\/or treating\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    radiation\u2010induced acute inflammation and photoaging.\n                  <\/jats:p>","DOI":"10.1111\/php.12628","type":"journal-article","created":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T04:56:42Z","timestamp":1470977802000},"page":"808-815","source":"Crossref","is-referenced-by-count":61,"title":["Protective Effect of Curcumin Against Acute Ultraviolet B Irradiation\u2010induced Photo\u2010damage"],"prefix":"10.1111","volume":"92","author":[{"given":"Huaping","family":"Li","sequence":"first","affiliation":[{"name":"Guangzhou Institute of Dermatology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aili","family":"Gao","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Dermatology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Jiang","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Dermatology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Dermatology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bihua","family":"Liang","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Dermatology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runxiang","family":"Li","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Dermatology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Dermatology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenjie","family":"Li","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Dermatology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Dermatology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2005.11.008"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2005.04.001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000064535"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C300048200"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2004.07.019"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2012.09.008"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12605921"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb00671.x"},{"key":"e_1_2_6_10_1","first-page":"6102","article-title":"Ultraviolet radiation and immunology: Something new under the sun\u2013presidential address","volume":"54","author":"Kripke M. 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