{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T03:42:55Z","timestamp":1790134975857,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T00:00:00Z","timestamp":1476748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR 001079"],"award-info":[{"award-number":["UL1 TR 001079"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Biofilms are difficult to eradicate due to a protective architecture and create major challenges in patient care by diminishing both host immune response and therapeutic approaches. This study investigated a new strategy for treating surface\u2010attached biofilms by delivering germicidal UV through a material surface in a process referred to as \u201cinside\u2010out sterilization\u201d (IOS). Mature\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    (ATCC\n                    <jats:sup>\u00ae<\/jats:sup>\n                    27853\n                    <jats:sup>\u2122<\/jats:sup>\n                    ) biofilms were irradiated with up to 1400 mJ cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    of germicidal UV from both ambient and IOS configurations. The lethal dose for the ambient exposure group was 461 mJ cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    95% CI [292, 728] compared to the IOS treatment group of 247 mJ cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    95% CI [187, 325], corresponding to 47% less UV dosage for the IOS group (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). This study demonstrated that with IOS, a lower quantal dosage of UV energy is required to eradicate biofilm than with ambient exposure by leveraging the organizational structure of the biofilm.\n                  <\/jats:p>","DOI":"10.1111\/php.12637","type":"journal-article","created":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T06:03:08Z","timestamp":1473660188000},"page":"835-841","source":"Crossref","is-referenced-by-count":5,"title":["Inside\u2010out Ultraviolet\u2010C Sterilization of\n                    <i>Pseudomonas aeruginosa<\/i>\n                    Biofilm\n                    <i>In Vitro<\/i>"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0142-6586","authenticated-orcid":false,"given":"Cameron C.","family":"Jones","sequence":"first","affiliation":[{"name":"The Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffi","family":"Valdeig","sequence":"additional","affiliation":[{"name":"The Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond M.","family":"Sova","sequence":"additional","affiliation":[{"name":"Photonics Division Johns Hopkins University Applied Physics Lab Laurel MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford R.","family":"Weiss","sequence":"additional","affiliation":[{"name":"The Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100247"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.2.155-166.2002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2911(02)46005-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2011.01.001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-007-0234-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3sm27705d"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2415"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.20.6558-6567.1991"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5418.1318"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.21838"},{"key":"e_1_2_6_12_1","unstructured":"NIH(2002)R21 Research on Microbial Biofilms (PA\u201003\u2010047). Available at:http:\/\/grants.nih.gov\/grants\/guide\/pa-files\/PA-03-047.html. Accessed on 18 July 2015."},{"key":"e_1_2_6_13_1","unstructured":"2008 Malvern PA USA Association for the Advancement of Wound Care (AAWC) Advancing your practice: understanding wound infection and the role of biofilms"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.1.43-48.2006"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306801"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200767030-00003"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.2.607"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/421946"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-01999-9"},{"key":"e_1_2_6_20_1","volume-title":"Biological Effects of Ultraviolet Radiation","author":"Harm W.","year":"1980"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2649"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.65.5.2025-2031.1999"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000354"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471725153"},{"key":"e_1_2_6_25_1","volume-title":"Overlapping Confidence Intervals and Statistical Significance","author":"Knezevic A.","year":"2008"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0043-1354(94)90042-6"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0290(19961020)52:2<340::AID-BIT14>3.0.CO;2-N"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(00)00136-9"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01569921"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0043-1354(95)00110-7"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jim.7000282"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2008.11.004"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2012.49"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2011.00962.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2010.04850.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1586\/eri.11.166"}],"container-title":["Photochemistry and Photobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fphp.12637","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fphp.12637","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/php.12637","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T13:41:41Z","timestamp":1696167701000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/php.12637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,18]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/php.12637"],"URL":"https:\/\/doi.org\/10.1111\/php.12637","archive":["Portico"],"relation":{},"ISSN":["0031-8655","1751-1097"],"issn-type":[{"value":"0031-8655","type":"print"},{"value":"1751-1097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,18]]}}}