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Incidence of melanoma has been increasing for decades. Although ultraviolet radiation (<jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>) has been identified as the most important environmental causative factor for melanoma development, <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\u2010protective strategies have had limited efficacy in melanoma prevention. <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> mutational burden correlates with melanoma development and tumor progression, underscoring the importance of <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> in melanomagenesis. However, besides amount of <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> exposure, melanocyte <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> mutational load is influenced by the robustness of nucleotide excision repair, the genome maintenance pathway charged with removing <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> photoproducts before they cause permanent mutations in the genome. In this review, we highlight the importance of the melanocortin hormonal signaling axis on regulating efficiency of nucleotide excision repair in melanocytes. By understanding the molecular mechanisms by which nucleotide excision repair can be increased, it may be possible to prevent many cases of melanoma by reducing <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> mutational burden over time.<\/jats:p>","DOI":"10.1111\/php.12640","type":"journal-article","created":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T00:26:41Z","timestamp":1474331201000},"page":"245-258","source":"Crossref","is-referenced-by-count":8,"title":["Hormonal Regulation of the Repair of UV Photoproducts in Melanocytes by the Melanocortin Signaling Axis"],"prefix":"10.1111","volume":"93","author":[{"given":"Stuart G.","family":"Jarrett","sequence":"first","affiliation":[{"name":"Markey Cancer Center University of Kentucky College of Medicine Lexington KY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"D'Orazio","sequence":"additional","affiliation":[{"name":"Markey Cancer Center University of Kentucky College of Medicine Lexington KY"},{"name":"Department of Toxicology and Cancer Biology University of Kentucky College of Medicine Lexington KY"},{"name":"Department of Physiology University of Kentucky College of Medicine Lexington KY"},{"name":"Department of Pharmacology and Nutritional Sciences University of Kentucky College of Medicine Lexington KY"},{"name":"Department of Pediatrics University of Kentucky College of Medicine Lexington KY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,17]]},"reference":[{"key":"e_1_2_13_2_1","first-page":"161","article-title":"Cutaneous malignant melanoma: A primary care perspective","volume":"85","author":"Shenenberger D. 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