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The cornea blocks a significant proportion of\n                    <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>\n                    from reaching the posterior structures of the eye. However,\n                    <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\n                    can penetrate the full thickness of the cornea, even reaching the anterior portion of the lens. Epidemiological data indicate that\n                    <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content>\n                    is a contributing factor for a multitude of diseases of the cornea including pterygium, photokeratitis, climatic droplet keratopathy and ocular surface squamous neoplasia (\n                    <jats:styled-content style=\"fixed-case\">OSSN<\/jats:styled-content>\n                    ), although the pathogenic mechanisms of each require further elucidation.\n                    <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content>\n                    is a well\u2010known genotoxic agent, and its effects have been well characterized in organs such as the skin. However, we are only beginning to identify its effects on the cornea, such as the\n                    <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content>\n                    signature C \u2192 T and\n                    <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>\n                    \u2192\n                    <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>\n                    transversions identified by sequencing and increased proliferative and shedding rates in response to\n                    <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content>\n                    exposure. Alarmingly, a single low\u2010dose exposure of\n                    <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content>\n                    to the cornea is sufficient to elicit genetic, molecular and cellular changes, supporting the consideration of using protective measures, such as wearing sunglasses when outdoors. The aim of this review was to describe the adverse effects of\n                    <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content>\n                    on the cornea.\n                  <\/jats:p>","DOI":"10.1111\/php.12686","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T09:05:42Z","timestamp":1481274342000},"page":"920-929","source":"Crossref","is-referenced-by-count":102,"title":["Damaging Effects of Ultraviolet Radiation on the Cornea"],"prefix":"10.1111","volume":"93","author":[{"given":"Naomi C.","family":"Delic","sequence":"first","affiliation":[{"name":"Discipline of Dermatology Bosch Institute University of Sydney Camperdown NSW Australia"},{"name":"Immune Imaging Program Centenary Institute for Cancer Medicine and Cell Biology Camperdown NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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