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Nature has developed unique flavoenzymes, called <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> photolyases, that utilize blue light, that is photons of lower energy than those of the damaging light, to repair these lesions. In this review, we focus on the chemically challenging repair of the (6\u20134) photoproducts by (6\u20134) photolyase and describe the major events along the quest for the reaction mechanisms, over the 20 years since the discovery of (6\u20104) photolyase.<\/jats:p>","DOI":"10.1111\/php.12696","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T20:27:14Z","timestamp":1482179234000},"page":"51-66","source":"Crossref","is-referenced-by-count":56,"title":["Repair of (6\u20104) Lesions in DNA by (6\u20104) Photolyase: 20 Years of Quest for the Photoreaction Mechanism"],"prefix":"10.1111","volume":"93","author":[{"given":"Junpei","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Division of Chemistry Graduate School of Engineering Science Osaka University Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Plaza","sequence":"additional","affiliation":[{"name":"Ecole Normale Sup\u00e9rieure PSL Research University UPMC Univ Paris 06 CNRS D\u00e9partement de Chimie PASTEUR Paris France"},{"name":"Sorbonne Universit\u00e9s UPMC Univ Paris 06 ENS CNRS PASTEUR Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Brettel","sequence":"additional","affiliation":[{"name":"Institute for Integrative Biology of the Cell (I2BC) IBITECS CEA CNRS Univ Paris\u2010Sud Universit\u00e9 Paris\u2010Saclay Gif\u2010sur\u2010Yvette France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2004.09.012"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.12197"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.16.11678"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi0022543"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00243a052"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"26732","DOI":"10.1016\/S0021-9258(19)61437-7","article-title":"Distribution and repair of bipyrimidine photoproducts in solar UV\u2010irradiated mammalian cells","volume":"275","author":"Perdiz D.","year":"2000","journal-title":"J. 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