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In this study, we investigated the potential of retinyl palmitate to enhance<jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content>\u2010induced photo\u2010co\u2010carcinogenesis. Groups of 36 male and 36 female<jats:styled-content style=\"fixed-case\">SKH<\/jats:styled-content>\u20101 hairless mice were exposed to simulated solar light (<jats:styled-content style=\"fixed-case\">SSL<\/jats:styled-content>) and treated with the control cream or creams containing retinyl palmitate, 5 days per week for 40 weeks. Other groups of mice were exposed to<jats:styled-content style=\"fixed-case\">SSL<\/jats:styled-content>and received no cream treatment or received cream treatments and were exposed to ultraviolet\u2010A or ultraviolet\u2010B. Mice were monitored for the development of skin tumors, and the incidences and multiplicities of squamous cell neoplasia were determined by histopathology. In both the absence and presence of<jats:styled-content style=\"fixed-case\">SSL<\/jats:styled-content>, mice administered the control cream developed skin tumors earlier and had higher incidences and multiplicities of skin squamous cell neoplasms than mice that received no cream treatment. Compared to the control cream groups, mice exposed to<jats:styled-content style=\"fixed-case\">SSL<\/jats:styled-content>and administered the retinyl palmitate creams demonstrated earlier onsets of skin tumors and had increased incidences and multiplicities of squamous cell skin neoplasms.<\/jats:p>","DOI":"10.1111\/php.12730","type":"journal-article","created":{"date-parts":[[2017,1,28]],"date-time":"2017-01-28T07:53:38Z","timestamp":1485590018000},"page":"1096-1114","source":"Crossref","is-referenced-by-count":4,"title":["Photo\u2010co\u2010carcinogenesis of Topically Applied Retinyl Palmitate in SKH\u20101 Hairless Mice"],"prefix":"10.1111","volume":"93","author":[{"given":"Mary D.","family":"Boudreau","sequence":"first","affiliation":[{"name":"Division of Biochemical Toxicology Food and Drug Administration National Center for Toxicological Research Jefferson Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick A.","family":"Beland","sequence":"additional","affiliation":[{"name":"Division of Biochemical Toxicology Food and Drug Administration National Center for Toxicological Research Jefferson Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert P.","family":"Felton","sequence":"additional","affiliation":[{"name":"Division of Bioinformatics and Biostatistics Food and Drug Administration National Center for Toxicological Research Jefferson Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter P.","family":"Fu","sequence":"additional","affiliation":[{"name":"Division of Biochemical Toxicology Food and Drug Administration National Center for Toxicological Research Jefferson Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul C.","family":"Howard","sequence":"additional","affiliation":[{"name":"Office of Scientific Coordination Food and Drug Administration National Center for Toxicological Research Jefferson Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul W.","family":"Mellick","sequence":"additional","affiliation":[{"name":"Jefferson Laboratories Toxicologic Pathology Associates, Inc. Jefferson Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brett T.","family":"Thorn","sequence":"additional","affiliation":[{"name":"Division of Bioinformatics and Biostatistics Food and Drug Administration National Center for Toxicological Research Jefferson Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg R.","family":"Olson","sequence":"additional","affiliation":[{"name":"Jefferson Laboratories Toxicologic Pathology Associates, Inc. Jefferson Arkansas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,28]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"479","article-title":"The biological effects of retinoids on cell differentiation and proliferation","volume":"26","author":"Favennec L.","year":"1988","journal-title":"J. Clin. Chem. Clin. 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