{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:44:51Z","timestamp":1785386691992,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T00:00:00Z","timestamp":1493251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["15\u201010897S"],"award-info":[{"award-number":["15\u201010897S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["IGA_LF_2016_012"],"award-info":[{"award-number":["IGA_LF_2016_012"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["RVO: 61989592"],"award-info":[{"award-number":["RVO: 61989592"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Quercetin, one of the most abundant polyphenols in the plant kingdom has been shown to be photodegraded on exposure to <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> light. Despite the fact, it is a component of several dermatological preparations. Its phototoxic potential has not been evaluated to date. The aim of this study was to assess whether photo\u2010induced degradation of quercetin is linked to phototoxic effects on living cells. Its dihydro derivative, taxifolin, was included in the study. For evaluation, the 3T3 Neutral Red Uptake Phototoxicity Test according to <jats:styled-content style=\"fixed-case\">OECD TG<\/jats:styled-content> 432 was used. To better approximate human skin, HaCaT keratinocytes, normal human epidermal keratinocytes and dermal fibroblasts were used, apart from the Balb\/c 3T3 cell line. Quercetin showed a dose\u2010dependent photodegradation in aqueous and organic environments and a phototoxic effect on all used cells. Quercetin pretreatment and following <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content> exposure resulted in increased reactive oxygen species production and intracellular glutathione level depletion in human dermal fibroblasts. Taxifolin was found completely nonphototoxic and photostable. As only <jats:italic>in vitro<\/jats:italic> methodology was used, further studies using 3D skin models and\/or human volunteers are needed to confirm whether exposure to sunlight, tanning sunbeds and\/or phototherapy in people using cosmetics containing quercetin is a health risk.<\/jats:p>","DOI":"10.1111\/php.12755","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T04:26:43Z","timestamp":1489724803000},"page":"1240-1247","source":"Crossref","is-referenced-by-count":31,"title":["The Phototoxic Potential of the Flavonoids, Taxifolin and Quercetin"],"prefix":"10.1111","volume":"93","author":[{"given":"Alena","family":"Rajnochov\u00e1 Svobodov\u00e1","sequence":"first","affiliation":[{"name":"Department of Medical Chemistry and Biochemistry Faculty of Medicine and Dentistry Palack\u00fd University Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena","family":"Ry\u0161av\u00e1","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry and Biochemistry Faculty of Medicine and Dentistry Palack\u00fd University Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Psotov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry and Biochemistry Faculty of Medicine and Dentistry Palack\u00fd University Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Kosina","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry and Biochemistry Faculty of Medicine and Dentistry Palack\u00fd University Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohumil","family":"Z\u00e1le\u0161\u00e1k","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery University Hospital Olomouc Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitka","family":"Ulrichov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry and Biochemistry Faculty of Medicine and Dentistry Palack\u00fd University Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitka","family":"Vost\u00e1lov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry and Biochemistry Faculty of Medicine and Dentistry Palack\u00fd University Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2003.019"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12218"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2015.09.018"},{"key":"e_1_2_7_5_1","first-page":"31","article-title":"Changes of the quercetin absorption spectra in dependence on solvent","volume":"1","author":"Bancirova M.","year":"2015","journal-title":"Chem. 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