{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:17:45Z","timestamp":1790234265758,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T00:00:00Z","timestamp":1500595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["145085"],"award-info":[{"award-number":["145085"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007177","name":"Comisi\u00f3n de Operaci\u00f3n y Fomento de Actividades Acad\u00e9micas, Instituto Polit\u00e9cnico Nacional","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007177","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009114","name":"California Health Care Safety Net Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009114","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photochem & Photobiology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"Abstract<\/jats:title>\n \n This study aimed to determine the effectiveness of photodynamic therapy (\n PDT<\/jats:styled-content>\n ), using \u03b4\u2010aminolevulinic acid (5\u2010\n ALA<\/jats:styled-content>\n ), in the elimination of premalignant cervical lesions in Mexican patients with human papillomavirus (\n HPV<\/jats:styled-content>\n ) infection and\/or cervical intraepithelial neoplasia (\n CIN<\/jats:styled-content>\n ). Thirty women diagnosed with\n CIN<\/jats:styled-content>\n I and\/or positive for\n HPV<\/jats:styled-content>\n participated in the study. Topical 6% 5\u2010\n ALA<\/jats:styled-content>\n in gel form was applied to the uterine cervix; after 4 h, the lesion area was irradiated with a light dose of 200 J cm\n \u22122<\/jats:sup>\n at 635 nm. This procedure was performed three times at 48\u2010h intervals. Clinical follow\u2010up was performed at 3, 6, and 12 months after the initial\n PDT<\/jats:styled-content>\n administration, by colposcopy, cervical cytology, histopathological analysis, polymerase chain reaction, and hybrid capture. Of\n HPV<\/jats:styled-content>\n \u2010infected patients without evidence of\n CIN<\/jats:styled-content>\n I, 80% cleared the infection, while\n HPV<\/jats:styled-content>\n associated with\n CIN<\/jats:styled-content>\n I was eliminated in 83% of patients (\n P<\/jats:italic>\n < 0.05). At 12 months,\n CIN<\/jats:styled-content>\n I had regressed in 57% of patients, although this response was not statistically significant.\n PDT<\/jats:styled-content>\n using 6% 5\u2010\n ALA<\/jats:styled-content>\n is concluded to be effective in eliminating\n HPV<\/jats:styled-content>\n infection associated or not with\n CIN<\/jats:styled-content>\n I.\n <\/jats:p>","DOI":"10.1111\/php.12769","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T18:31:59Z","timestamp":1491417119000},"page":"1269-1275","source":"Crossref","is-referenced-by-count":32,"title":["Effectiveness of Photodynamic Therapy in Elimination of HPV\u201016 and HPV\u201018 Associated with CIN I in Mexican Women"],"prefix":"10.1111","volume":"93","author":[{"given":"Elizabeth","family":"Maldonado Alvarado","sequence":"first","affiliation":[{"name":"Laboratorio de Citopatolog\u00eda Ambiental Departamento de Morfolog\u00eda Escuela Nacional de Ciencias Biol\u00f3gicas Instituto Polit\u00e9cnico Nacional (IPN) Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha Olivia","family":"Osorio Peralta","sequence":"additional","affiliation":[{"name":"Instituto Estatal de Cancerolog\u00eda de Guerrero \u201cDr. Arturo Beltr\u00e1n Ortega\u201d Acapulco Guerrero M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Moreno V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Departamento de Patolog\u00eda Hospital de Cardiolog\u00eda Centro M\u00e9dico Nacional Siglo XXI Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia Alejandra","family":"Mart\u00ednez Guzm\u00e1n","sequence":"additional","affiliation":[{"name":"Centro de Salud T\u2010III M\u00e9xico\u2010Espa\u00f1a Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Eugenia","family":"Melo Petrone","sequence":"additional","affiliation":[{"name":"Comit\u00e9 para la Educaci\u00f3n y Desarrollo Integral de la Mujer A.C. 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San Andr\u00e9s Tuxtla Veracruz M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Linda","family":"Bello Leiva","sequence":"additional","affiliation":[{"name":"Laboratorio de Citopatolog\u00eda Ambiental Departamento de Morfolog\u00eda Escuela Nacional de Ciencias Biol\u00f3gicas Instituto Polit\u00e9cnico Nacional (IPN) Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Araceli","family":"Espinosa Montesinos","sequence":"additional","affiliation":[{"name":"Cl\u00ednica de Displasias Hospital Regional \u201cGral. 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