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However, much remains to be understood about the regulation of the\n                    <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\n                    damage response in melanocytes and melanoma. Here, we show that\n                    <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\n                    , but not the shorter waveband\n                    <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>\n                    (280\u2013315 nm), up\u2010regulates adaptor protein p62 in an Nrf2\u2010 and reactive oxygen species (\n                    <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>\n                    )\u2010dependent manner, suggesting a\n                    <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\n                    \u2010specific effect on p62 regulation.\n                    <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\n                    \u2010induced p62 up\u2010regulation was inhibited by a mitochondria\u2010targeted antioxidant or Nrf2 knockdown. In addition, p62 knockdown inhibited\n                    <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\n                    \u2010induced\n                    <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>\n                    production and Nrf2 up\u2010regulation. We also report here a novel regulatory feedback loop between p62 and\n                    <jats:styled-content style=\"fixed-case\">PTEN<\/jats:styled-content>\n                    in melanoma cells.\n                    <jats:styled-content style=\"fixed-case\">PTEN<\/jats:styled-content>\n                    overexpression reduced p62 protein levels, and p62 knockdown increased\n                    <jats:styled-content style=\"fixed-case\">PTEN<\/jats:styled-content>\n                    protein levels. As compared with normal human skin, p62 was up\u2010regulated in human nevus, malignant melanoma and metastatic melanoma. Furthermore, p62 was up\u2010regulated in melanoma cells relative to normal human epidermal melanocytes, independent of their\n                    <jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content>\n                    or\n                    <jats:styled-content style=\"fixed-case\">NRAS<\/jats:styled-content>\n                    mutation status. Our results demonstrated that\n                    <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\n                    up\u2010regulates p62 and induces a p62\u2010Nrf2 positive feedback loop to counteract oxidative stress. Additionally, p62 forms a feedback loop with\n                    <jats:styled-content style=\"fixed-case\">PTEN<\/jats:styled-content>\n                    in melanoma cells, suggesting p62 functions as an oncogene in\n                    <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\n                    \u2010associated melanoma development and progression.\n                  <\/jats:p>","DOI":"10.1111\/php.12809","type":"journal-article","created":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T11:02:47Z","timestamp":1500289367000},"page":"432-437","source":"Crossref","is-referenced-by-count":29,"title":["The Autophagy Receptor Adaptor p62 is Up\u2010regulated by\n                    <scp>UVA<\/scp>\n                    Radiation in Melanocytes and in Melanoma Cells"],"prefix":"10.1111","volume":"94","author":[{"given":"Ashley","family":"Sample","sequence":"first","affiliation":[{"name":"Department of Medicine Section of Dermatology University of Chicago Chicago IL"},{"name":"Committee on Cancer Biology University of Chicago Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baozhong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Medicine Section of Dermatology University of Chicago Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunli","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The Fourth Hospital China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences North Dakota State University Fargo ND"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianglin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Cancer Biology College of Medicine University of Kentucky Lexington KY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Aplin","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology Kimmel Cancer Center Thomas Jefferson University Philadelphia PA"},{"name":"Department of Dermatology and Cutaneous Biology Thomas Jefferson University Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Ying","family":"He","sequence":"additional","affiliation":[{"name":"Department of Medicine Section of Dermatology University of Chicago Chicago IL"},{"name":"Committee on Cancer Biology University of Chicago Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,8]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","article-title":"World cancer factsheet","volume":"4","author":"World Health Organization, Cancer Research UK","year":"2014","journal-title":"World Health Organ"},{"key":"e_1_2_6_3_1","unstructured":"Skin Cancer Foundation(2015).Skin Cancer Facts & Statistics. 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