{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:29:23Z","timestamp":1759962563584},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:00:00Z","timestamp":1516320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003663","name":"Small and Medium Business Administration","doi-asserted-by":"publisher","award":["S2297176"],"award-info":[{"award-number":["S2297176"]}],"id":[{"id":"10.13039\/501100003663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Sorbus commixta<\/jats:italic> is a traditional oriental medicinal plant that grows in East Asian countries such as Korea, Japan and China. The twig of <jats:italic>S.\u00a0commixta<\/jats:italic> has been considered valuable for centuries to treat diseases including asthma, cough and other bronchial disorders. However, the effect of <jats:italic>S.\u00a0commixta<\/jats:italic> twig extract on human skin has not been investigated well. The present study aimed at assessing the antiphotoaging effect of <jats:italic>S.\u00a0commixta<\/jats:italic> twig ethanol extract (<jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content>) on ultraviolet B (<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>)\u2010induced matrix metalloproteinase (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>) levels and its underlying mechanism in human dermal fibroblasts. In this study, we found that <jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content> (12.5\u201350\u00a0<jats:italic>\u03bc<\/jats:italic>g\u00a0mL<jats:sup>\u22121<\/jats:sup>) treatment significantly inhibited <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>\u2010induced <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20101, <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20102 and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20103 expression, concomitant with a downregulation of intracellular <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content> generation. These effects might be associated with a <jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content>\u2010induced inhibition of the mitogen\u2010activated protein kinase (<jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content>) pathway. Furthermore, <jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content> also downregulated <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>\u2010induced c\u2010Fos expression in a concentration\u2010dependent manner, but had no inhibitory effect on c\u2010Jun phosphorylation. Taken together, these results indicate that <jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content> may be an antiphotoaging agent and that its effect may occur via its inhibition of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>s expression and <jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content> pathway activation.<\/jats:p>","DOI":"10.1111\/php.12868","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T09:02:41Z","timestamp":1511341361000},"page":"370-377","source":"Crossref","is-referenced-by-count":7,"title":["Suppression of Ultraviolet B\u2010mediated Matrix Metalloproteinase Generation by <i>Sorbus commixta<\/i> Twig Extract in Human Dermal Fibroblasts"],"prefix":"10.1111","volume":"94","author":[{"given":"Song Hua","family":"Xuan","sequence":"first","affiliation":[{"name":"Department of Fine Chemistry Cosmetic R&amp;D Center Cosmetic Industry Coupled Collaboration Center Seoul National University of Science and Technology Nowon\u2010gu Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Min","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Fine Chemistry Cosmetic R&amp;D Center Cosmetic Industry Coupled Collaboration Center Seoul National University of Science and Technology Nowon\u2010gu Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Fine Chemistry Cosmetic R&amp;D Center Cosmetic Industry Coupled Collaboration Center Seoul National University of Science and Technology Nowon\u2010gu Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo Jin","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Fine Chemistry Cosmetic R&amp;D Center Cosmetic Industry Coupled Collaboration Center Seoul National University of Science and Technology Nowon\u2010gu Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Nam","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Fine Chemistry Cosmetic R&amp;D Center Cosmetic Industry Coupled Collaboration Center Seoul National University of Science and Technology Nowon\u2010gu Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.03.039"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1568-1637(02)00024-7"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a015370"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1711.2001.01047.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.08.013"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.28.1239"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.12.032"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2017.01.003"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules17033093"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3746\/jkfn.2010.39.10.1418"},{"key":"e_1_2_6_12_1","first-page":"403","article-title":"Anticancer effect of Sorbus commixta Hedl extracts","volume":"10","author":"Kyoung L. 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