{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:43Z","timestamp":1772160883232,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T00:00:00Z","timestamp":1519948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Photosensitizers are used in the treatment of epidermal proliferation and differentiation disorders such as psoriasis and vitiligo. In these studies, a ring\u2010expanded carbon homolog of\u00a0the linear psoralen (furo[3,2\u2010g]benzopyran\u20107\u2010one) class of\u00a0photosensitizers, 4,10\u2010dimethyl\u2010\n                    <jats:italic>2H,8H<\/jats:italic>\n                    \u2010benzo[1,2\u2010\n                    <jats:italic>b<\/jats:italic>\n                    :5,4\u2010\n                    <jats:italic>b\u2032<\/jats:italic>\n                    ]dipyran\u20102\u2010one (NDH2476), was synthesized and analyzed for biological activity. Following activation by ultraviolet light (UVA, 320\u2010400\u00a0nm), NDH2476 was found to be a potent inhibitor of keratinocyte growth (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a09\u00a0n\n                    <jats:sc>m<\/jats:sc>\n                    ). Similar derivatives methylated in the pyran ring, or containing a saturated pyran ring structure, were markedly less active or inactive as photosensitizers. NDH2476 was found to intercalate and damage DNA following UVA light treatment as determined by plasmid DNA unwinding and nicking experiments. Taken together, these data demonstrate that an intact furan ring in psoralen photosensitizers is not required for keratinocyte growth inhibition or DNA damage. Our findings that low nanomolar concentrations of a benzopyranone derivative were active as a photosensitizer indicates that this or a structurally related compound may be useful in the treatment of skin diseases involving aberrant epidermal cell growth and differentiation.\n                  <\/jats:p>","DOI":"10.1111\/php.12882","type":"journal-article","created":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T22:38:26Z","timestamp":1515537506000},"page":"577-582","source":"Crossref","is-referenced-by-count":6,"title":["Identification of a Pyranocoumarin Photosensitizer that is a Potent Inhibitor of Keratinocyte Growth"],"prefix":"10.1111","volume":"94","author":[{"given":"Jeffrey D.","family":"Laskin","sequence":"first","affiliation":[{"name":"Environmental and Occupational Health Sciences Institute Rutgers University School of Public Health Piscataway NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Hua","family":"Jan","sequence":"additional","affiliation":[{"name":"Environmental and Occupational Health Sciences Institute Rutgers University School of Public Health Piscataway NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele M.","family":"Jetter","sequence":"additional","affiliation":[{"name":"Department of Chemistry Lehigh University Bethlehem PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe D.","family":"Guillon","sequence":"additional","affiliation":[{"name":"Department of Chemistry Lehigh University Bethlehem PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas M.","family":"Mariano","sequence":"additional","affiliation":[{"name":"Environmental and Occupational Health Sciences Institute Rutgers University School of Public Health Piscataway NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane E.","family":"Heck","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Science New York Medical College Valhalla NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ned D.","family":"Heindel","sequence":"additional","affiliation":[{"name":"Department of Chemistry Lehigh University Bethlehem PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,2]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15969"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000412092"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct072317"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12366"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.109.5.674"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.0002"},{"key":"e_1_2_4_8_1","first-page":"597","article-title":"Phototherapy of mycosis fungoides","volume":"152","author":"Trautinger F.","year":"2017","journal-title":"G Ital Dermatol Venereol"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2016.11.001"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(91)90031-G"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867043363721"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/90300050"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000251450"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.1977.tb00727.x"},{"key":"e_1_2_4_15_1","unstructured":"Heindel N. D. M. C.Jetter J. D.LaskinandM. A.Gallo(1993)7\u2010Alkoxycoumarins dihydropsoralens and benzodipyranones as photo\u2010activated therapeutic agents and inhibitors of epidermal growth factor. US patent 5216176."},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00169a045"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.5570270433"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600800715"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(01)00855-3"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(02)00992-9"},{"key":"e_1_2_4_21_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.18388\/abp.1996_4557","article-title":"Psoralen photosensitization: Damages to nucleic acid and membrane lipid components","volume":"43","author":"Caffieri S.","year":"1996","journal-title":"Acta Biochim. 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