{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T20:44:43Z","timestamp":1785012283047,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T00:00:00Z","timestamp":1540771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Natural extracts (<jats:styled-content style=\"fixed-case\">NE<\/jats:styled-content>) with antioxidant properties can minimize the effects of photoaging. Photobiomodulation (<jats:styled-content style=\"fixed-case\">PBM<\/jats:styled-content>) has proven to be a useful tool for the modulation of cell metabolism. Here, we investigate the associations of antioxidants with <jats:styled-content style=\"fixed-case\">PBM<\/jats:styled-content> with the aim of promoting skin rejuvenation. We began with standardization of the experimental protocol. Extracts of chamomile, rosemary, blueberry, green tea, figs, pomegranate and nutwood were tested. A custom irradiation system (366\u00a0\u00b1\u00a010\u00a0nm) was used to simulate sun exposure. A light emitting diode system (640\u00a0\u00b1\u00a012.5\u00a0nm) was used for <jats:styled-content style=\"fixed-case\">PBM<\/jats:styled-content>. Viability assessments were performed by the (3\u2010(4,5\u2010Dimethyl\u20102\u2010thiazolyl)\u20102,5\u2010diphenyl\u20102H\u2010tetrazolium bromide) MTT assay method. Based on the results, radiant exposure to <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content> was defined as 9 and 1\u00a0J\u00a0cm<jats:sup>\u22122<\/jats:sup> for <jats:styled-content style=\"fixed-case\">PBM<\/jats:styled-content>. Extract concentrations were established on the basis of dark toxicities, which ranged from 0.01% to 0.3%. The data show that <jats:styled-content style=\"fixed-case\">PBM<\/jats:styled-content> is a promising therapy to restore keratinocytes after <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content> damage; however, the detailed mechanism and effects require further exploration. Moreover, although the combination of <jats:styled-content style=\"fixed-case\">PBM<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">NE<\/jats:styled-content> may be a useful strategy, the choice of a <jats:styled-content style=\"fixed-case\">NE<\/jats:styled-content> is challenging, since the working concentration and other properties, such as photosensitivity, may bring about unwanted results.<\/jats:p>","DOI":"10.1111\/php.13026","type":"journal-article","created":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T12:58:14Z","timestamp":1538225894000},"page":"644-649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Combination of Natural Extracts and Photobiomodulation in Keratinocytes Subjected to UVA Radiation"],"prefix":"10.1111","volume":"95","author":[{"given":"Elineides Santos","family":"Silva","sequence":"first","affiliation":[{"name":"Post Graduate Program of Biophotonics Applied to Health Sciences Universidade Nove de Julho\u2010UNINOVE S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Benedito","family":"Machado","sequence":"additional","affiliation":[{"name":"Post Graduate Program of Biophotonics Applied to Health Sciences Universidade Nove de Julho\u2010UNINOVE S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Lino\u2010dos\u2010Santos\u2010Franco","sequence":"additional","affiliation":[{"name":"Post Graduate Program of Biophotonics Applied to Health Sciences Universidade Nove de Julho\u2010UNINOVE S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8275-7370","authenticated-orcid":false,"given":"Christiane","family":"Pavani","sequence":"additional","affiliation":[{"name":"Post Graduate Program of Biophotonics Applied to Health Sciences Universidade Nove de Julho\u2010UNINOVE S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,29]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"78","article-title":"Safety of UV radiation for autofluorescence diagnosis of skin cancer","volume":"52","author":"Delgado J. 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