{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T17:23:39Z","timestamp":1768584219873,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P01\u2010CA087971"],"award-info":[{"award-number":["P01\u2010CA087971"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01\u2010CA85831"],"award-info":[{"award-number":["R01\u2010CA85831"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inflammatory cells, most especially neutrophils, can be a necessary component of the antitumor activity occurring after administration of photodynamic therapy. Generation of neutrophil responses has been suggested to be particularly important in instances when the delivered photodynamic therapy (PDT) dose is insufficient. In these cases, the release of neutrophil granules and engagement of antitumor immunity may play an important role in eliminating residual disease. Herein, we utilize <jats:italic>in\u00a0vivo<\/jats:italic> imaging of luminol chemiluminescence to noninvasively monitor neutrophil activation after <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> administration. Studies were performed in the AB12 murine model of mesothelioma, treated with Photofrin\u2010<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>. Luminol\u2010generated chemiluminescence increased transiently 1\u00a0h after <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>, followed by a subsequent decrease at 4\u00a0h after <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>. The production of luminol signal was not associated with the influx of Ly6G<jats:sup>+<\/jats:sup> cells, but was related to oxidative burst, as an indicator of neutrophil function. Most importantly, greater levels of luminol chemiluminescence 1\u00a0h after <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> were prognostic of a complete response at 90\u00a0days after <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>. Taken together, this research supports an important role for early activity by Ly6G<jats:sup>+<\/jats:sup> cells in the generation of long\u2010term <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> responses in mesothelioma, and it points to luminol chemiluminescence as a potentially useful approach for preclinical monitoring of neutrophil activation by <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/php.13040","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T10:55:54Z","timestamp":1540464954000},"page":"430-438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Luminol Chemiluminescence Reports Photodynamic Therapy\u2010Generated Neutrophil Activity <i>In Vivo<\/i> and Serves as a Biomarker of Therapeutic Efficacy"],"prefix":"10.1111","volume":"95","author":[{"suffix":"IV","given":"Richard W.","family":"Davis","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Perelman School of Medicine University of Pennsylvania Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Snyder","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Perelman School of Medicine University of Pennsylvania Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joann","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Perelman School of Medicine University of Pennsylvania Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirron","family":"Carter","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Perelman School of Medicine University of Pennsylvania Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassandra","family":"Houser","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Perelman School of Medicine University of Pennsylvania Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astero","family":"Klampatsa","sequence":"additional","affiliation":[{"name":"Department of Medicine Perelman School of Medicine University of Pennsylvania Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven M.","family":"Albelda","sequence":"additional","affiliation":[{"name":"Department of Medicine Perelman School of Medicine University of Pennsylvania Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith A.","family":"Cengel","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Perelman School of Medicine University of Pennsylvania Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa M.","family":"Busch","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Perelman School of Medicine University of Pennsylvania Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0pp00354a"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600864"},{"key":"e_1_2_7_4_1","first-page":"3904","article-title":"Altered expression of interleukin 6 and interleukin 10 as a result of photodynamic therapy in\u00a0vivo","volume":"57","author":"Gollnick S. O.","year":"1997","journal-title":"Cancer Res."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/82.1.34"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/b204254a"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.21107"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-009-8119-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1572-1000(05)00098-0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1995.475"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/983698"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2003.10.004"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-1778"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-3513"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.08.071"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22934"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.18.10.101314"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3RU0615-256R"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(89)90070-1"},{"key":"e_1_2_7_20_1","first-page":"41","article-title":"Luminol\u2010amplified chemiluminescence detects mainly superoxide anion produced by human neutrophils","volume":"7","author":"Bedouhene S.","year":"2017","journal-title":"Am. J. Blood Res."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041510305"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1886"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2013.08.017"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2012.08.007"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1162\/1535350042380290"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.11.029"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2015.01.028"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.02.009"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2349817"},{"key":"e_1_2_7_30_1","first-page":"91","article-title":"Effects of dimethyl sulfoxide on the oxidative function of human neutrophils","volume":"110","author":"Beilke M. A.","year":"1987","journal-title":"J. Lab. Clin. Med."},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2002.6724"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000131784.50633.4f"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1179\/135100006X116592"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2011.01370.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/iai.45.1.1-5.1984","article-title":"Intra\u2010 and extracellular events in luminol\u2010dependent chemiluminescence of polymorphonuclear leukocytes","volume":"45","author":"Briheim G.","year":"1984","journal-title":"Infect. Immunol."},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.48.1.56"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(02)00015-3"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103621"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-456483"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers8100094"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12150"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.06.017"}],"container-title":["Photochemistry and Photobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fphp.13040","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/php.13040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T04:38:48Z","timestamp":1694666328000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/php.13040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,26]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/php.13040"],"URL":"https:\/\/doi.org\/10.1111\/php.13040","archive":["Portico"],"relation":{},"ISSN":["0031-8655","1751-1097"],"issn-type":[{"value":"0031-8655","type":"print"},{"value":"1751-1097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,26]]},"assertion":[{"value":"2018-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}