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In this work, we study the interaction of the singlet and triplet excited states of pterin (Ptr), the parent compound of oxidized pterins, with four oxidizable amino acids: tryptophan (Trp), tyrosine (Tyr), histidine (His) and methionine (Met). Steady\u2010state and time\u2010resolved fluorescence measurements and laser flash photolysis experiments were performed to investigate the quenching of the Ptr excited states by the amino acids in aqueous solution. The singlet excited states of Ptr are quenched by Met mainly <jats:italic>via<\/jats:italic> a dynamic process and by Trp <jats:italic>via<\/jats:italic> a combination of dynamic and static processes. His does not quench singlet excited states of Ptr, and quenching by Tyr could not be investigated due to the low solubility of this amino acid. The triplet excited states of Ptr are quenched by the four studied amino acids, and the corresponding bimolecular quenching rate constants are in the range of diffusion controlled limit. The assessment of the results in the context of the Ptr\u2010photosensitization of amino acids suggests that triplet excited state of Ptr is the species that initiates the photochemical processes.<\/jats:p>","DOI":"10.1111\/php.13046","type":"journal-article","created":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T12:59:46Z","timestamp":1541595586000},"page":"220-226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Quenching of the Singlet and Triplet Excited States of Pterin by Amino Acids"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5303-6475","authenticated-orcid":false,"given":"Carolina","family":"Casta\u00f1o","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones Fisicoqu\u00edmicas Te\u00f3ricas y Aplicadas (INIFTA) Departamento de Qu\u00edmica Facultad de Ciencias Exactas Universidad Nacional de La Plata CCT La Plata\u2010CONICET La Plata Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2476-6794","authenticated-orcid":false,"given":"Mariana P.","family":"Serrano","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Fisicoqu\u00edmicas Te\u00f3ricas y Aplicadas (INIFTA) Departamento de Qu\u00edmica Facultad de Ciencias Exactas Universidad Nacional de La Plata CCT La Plata\u2010CONICET La Plata Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Lorente","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Fisicoqu\u00edmicas Te\u00f3ricas y Aplicadas (INIFTA) Departamento de Qu\u00edmica Facultad de Ciencias Exactas Universidad Nacional de La Plata CCT La Plata\u2010CONICET La Plata Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0120-645X","authenticated-orcid":false,"given":"Claudio D.","family":"Borsarelli","sequence":"additional","affiliation":[{"name":"Instituto de Bionanotecnolog\u00eda del NOA (INBIONATEC) CONICET Universidad Nacional de Santiago del Estero (UNSE) Santiago del Estero Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8054-7799","authenticated-orcid":false,"given":"Andr\u00e9s H.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Fisicoqu\u00edmicas Te\u00f3ricas y Aplicadas (INIFTA) Departamento de Qu\u00edmica Facultad de Ciencias Exactas Universidad Nacional de La Plata CCT La Plata\u2010CONICET La Plata Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar050151c"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/7081_2007_061"},{"issue":"4","key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1515\/pteridines.2009.20.1.124","article-title":"Theoretical study of the relative energies of anionic pterin tautomers","volume":"20","author":"Soniat M.","year":"2009","journal-title":"Pteridines"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.2610100104"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr9402034"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8128228"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20090603"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2002.6727"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2001.00220.x"},{"issue":"9","key":"e_1_2_7_11_1","first-page":"1149","article-title":"Phosphorescence analysis of the triplet state of pterins in connection with their photoreceptor function in biochemical systems","volume":"61","author":"Neverov K. 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