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Low\u2010level laser therapy (<jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content>) has demonstrated positive results as a treatment option for <jats:styled-content style=\"fixed-case\">PNI<\/jats:styled-content>. Wistar rats were divided into five groups: Control, Injury, Injury\u00a0+\u00a0LLLTn (nerve), Injury\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content>m (muscle) and Injury\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content>n\u00a0+\u00a0m (nerve and muscle irradiation). The groups were analyzed after one, two, three and four weeks. <jats:styled-content style=\"fixed-case\">PNI<\/jats:styled-content> was achieved by crushing the sciatic nerve. Laser treatment (780\u00a0nm, 3.2\u00a0J) was realized over the nerve and\/or tibialis anterior muscle. In gait analyses, the groups irradiated over the nerve demonstrated an improvement after two weeks. In the analysis of mechanical sensitivity, the Injury\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content>n demonstrated a reduction after one week in comparison with Injury group; the Injury\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content>n\u00a0+\u00a0m and Injury\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content>m demonstrated an increase after two weeks in comparison with Injury group; and the irradiated groups demonstrated a reduction in nociception after four weeks in comparison with Injury group. In the analysis of muscle atrophy, the Injury\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content>n demonstrated more muscle mass after two weeks. <jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content> improves functional aspects related to gait, mechanical sensitivity and muscle mass, with better results regarding motor aspects and muscle mass when administered over the injured nerve and better results regarding sensory aspects when administered over the muscle.<\/jats:p>","DOI":"10.1111\/php.13048","type":"journal-article","created":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T11:15:47Z","timestamp":1541762147000},"page":"879-885","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of Photobiomodulation on Functionality in Wistar Rats with Sciatic Nerve Injury"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8313-4300","authenticated-orcid":false,"given":"Lucas","family":"Andreo","sequence":"first","affiliation":[{"name":"Postgraduate Program in Biophotonics Applied to Health Sciences University Nove de Julho (UNINOVE) S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla A.","family":"Soldera","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Rehabilitation Sciences UNINOVE S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz Guimar\u00e3es","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Rehabilitation Sciences UNINOVE S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick Raoul Vicente","family":"de Matos","sequence":"additional","affiliation":[{"name":"Universidade Nove de Julho UNINOVE S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola Bindes","family":"Sousa","sequence":"additional","affiliation":[{"name":"Universidade Nove de Julho UNINOVE S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weslley Wallace","family":"de Alc\u00e2ntara Ara\u00fajo Amorim","sequence":"additional","affiliation":[{"name":"Universidade Nove de Julho UNINOVE S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Carolina Ratto Tempestini","family":"Horliana","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biophotonics Applied to Health Sciences University Nove de Julho (UNINOVE) S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra Kalil","family":"Bussadori","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biophotonics Applied to Health Sciences University Nove de Julho (UNINOVE) S\u00e3o Paulo SP Brazil"},{"name":"Postgraduate Program in Rehabilitation Sciences UNINOVE S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristianne Porta Santos","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biophotonics Applied to Health Sciences University Nove de Julho (UNINOVE) S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5142-9526","authenticated-orcid":false,"given":"Raquel Agnelli","family":"Mesquita\u2010Ferrari","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biophotonics Applied to Health Sciences University Nove de Julho (UNINOVE) S\u00e3o Paulo SP Brazil"},{"name":"Postgraduate Program in Rehabilitation Sciences UNINOVE S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e31815e6370"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.55614"},{"key":"e_1_2_9_4_1","first-page":"2nd ed.","volume-title":"Surgical Disorders of the Peripheral Nerves","author":"Seddon H. 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