{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T18:56:08Z","timestamp":1786215368047,"version":"build-2736575974"},"reference-count":82,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T00:00:00Z","timestamp":1545955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Malignant pleural mesothelioma remains difficult to treat, with high failure rates despite optimal therapy. We present a novel prospective trial combining proton therapy (<jats:styled-content style=\"fixed-case\">PT<\/jats:styled-content>) and photodynamic therapy (<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>) and the largest\u2010ever mesothelioma <jats:styled-content style=\"fixed-case\">PT<\/jats:styled-content> experience (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>10). <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> photosensitizers included porfimer sodium (2\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup>; 24\u00a0h drug\u2010light interval) or 2\u2010[1\u2010hexyloxyethyl]\u20102\u2010devinyl pyropheophorbide\u2010a (<jats:styled-content style=\"fixed-case\">HPPH<\/jats:styled-content>) (4\u00a0mg\u00b7m<jats:sup>\u22122<\/jats:sup>;48\u00a0h) with wavelengths of 630\u00a0nm to 60J\u00b7cm<jats:sup>\u22122<\/jats:sup> and 665\u00a0nm to 15\u201045J\u00b7cm<jats:sup>\u22122<\/jats:sup>, respectively. With a median age of 69\u00a0years, patients were predominantly male (90%) with epithelioid histology (100%) and stage <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> disease (100%). <jats:styled-content style=\"fixed-case\">PT<\/jats:styled-content> was delivered to a median of 55.0 <jats:styled-content style=\"fixed-case\">CGE<\/jats:styled-content>\/1.8\u20102.0 <jats:styled-content style=\"fixed-case\">CGE<\/jats:styled-content> (range 50\u201375 <jats:styled-content style=\"fixed-case\">CGE<\/jats:styled-content>) adjuvantly (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>8) or as salvage therapy (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>2) following extended pleurectomy\/decortication (<jats:styled-content style=\"fixed-case\">ePD<\/jats:styled-content>)\/<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>. Two\u2010year local control was 90%, with distant and regional failure rates of 50% and 30%, respectively. All patients received chemotherapy, and four received immunotherapy. Surgical complications included atrial fibrillation (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>3), pneumonia (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>2), and deep vein thrombosis (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>2). Median survival from <jats:styled-content style=\"fixed-case\">PT<\/jats:styled-content> completion was 19.5\u00a0months (30.3\u00a0months from diagnosis), and 1\u2010 and 2\u2010year survival rates were 58% and 29%. No patient experienced <jats:styled-content style=\"fixed-case\">CTCAE<\/jats:styled-content>v4 grade \u22652 acute or late toxicity. Our prolonged survival in very advanced\u2010stage patients compares favorably to survival for <jats:styled-content style=\"fixed-case\">PT<\/jats:styled-content> without <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> and photon therapy with <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>, suggesting possible spatial or systemic cooperativity and immune effect.<\/jats:p>","DOI":"10.1111\/php.13065","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T19:28:47Z","timestamp":1543433327000},"page":"411-418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["A Novel Prospective Study Assessing the Combination of Photodynamic Therapy and Proton Radiation Therapy: Safety and Outcomes When Treating Malignant Pleural Mesothelioma"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2661-935X","authenticated-orcid":false,"given":"Stephanie R.","family":"Rice","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of Maryland School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun R.","family":"Li","sequence":"additional","affiliation":[{"name":"Helen Diller Family Comprehensive Cancer Center Department of Radiation Oncology University of California San Francisco San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa M.","family":"Busch","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Perelman School of Medicine University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele M.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Perelman School of Medicine University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"McNulty","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Perelman School of Medicine University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Dimofte","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Perelman School of Medicine University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Perelman School of Medicine University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith A.","family":"Cengel","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Perelman School of Medicine University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"Charles B.","family":"Simone","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Maryland School of Medicine Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,28]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"273","volume-title":"Textbook of Lung Cancer","author":"Scott B.","year":"2000"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050152"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh025"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2016.09.124"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.12.041"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000064"},{"issue":"6","key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1183\/09031936.94.07061035","article-title":"Prognostic factors and survival in malignant pleural mesothelioma","volume":"7","author":"Van Gelder T.","year":"1994","journal-title":"Eur. Respir. J."},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2018.08.007"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.1.145"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31815608d9"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-200506000-00001"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/030089160208800403"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181f1cf2b"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.8.1157"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.01.050"},{"issue":"6","key":"e_1_2_6_17_1","first-page":"E254","article-title":"Guidelines for the diagnosis and treatment of malignant pleural mesothelioma","volume":"5","author":"Zandwijk N.","year":"2013","journal-title":"J. Thorac. Dis."},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.11.136"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20005.14.589"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31826915f1"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2013.01.039"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2017.08.012"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2013.11.026"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00130404-200203000-00009"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevEukarGeneExpr.v16.i4.10"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/b311900a"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.3495720"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers8090083"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2014.09.017"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp051163i"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.10.5.12616"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.02.009"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.08.071"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02303746"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphy.2015.00009"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.4.1167"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-9293(03)00213-5"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)04474-0"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.02.062"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841869609109921"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(89)90266-6"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(82)90379-0"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00409-X"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.108.3.754"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2007.05.022"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601957"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2015.09.129"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.03.011"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.03.012"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.07.65"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2018.04.019"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-011-0038-3"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.11.006"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr.2018.04.07"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.2032"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.10.001"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30870"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2017.04.022"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2016.02.003"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2016.10.018"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-26-305-234"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1112824"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.02.022"},{"key":"e_1_2_6_64_1","first-page":"443","volume-title":"Anticancer Drugs","author":"Canti G.","year":"1994"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-0400"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0pp00354a"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.01.055"},{"key":"e_1_2_6_68_1","first-page":"1","article-title":"Real\u2010time treatment light dose guidance of Pleural PDT: An update","volume":"9308","author":"Zhu T. C.","year":"2015","journal-title":"Proc. SPIE Int. Soc. Opt. Eng."},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9101(2000)26:3<292::AID-LSM7>3.0.CO;2-T"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1117\/12.474144"},{"key":"e_1_2_6_71_1","article-title":"Detector calibration factor for interstitial in\u2010vivo light dosimetry using isotropic detectors with scattering tip","volume":"5689","author":"Zhu T. C.","year":"2005","journal-title":"Proc. SPIE Int. Soc. Opt. Eng."},{"key":"e_1_2_6_72_1","first-page":"71640A","volume-title":"Proceedings of SPIE","author":"Dimofte A.","year":"2009"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2001.116560"},{"key":"e_1_2_6_74_1","unstructured":"Li Y. R. E. W.Alley J. S.Friedberg M. J.Culligan T. M.Busch S. M.Hahn K. A.CengelandC. B.Simone2nd(2015)Prospective Assessment of Proton Therapy for Malignant Pleural Mesothelizoma. International Association for the Study of Lung Cancer. 16th World Conference on Lung Cancer."},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-015-0118-2"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3pp50333j"},{"issue":"1","key":"e_1_2_6_77_1","first-page":"63","article-title":"Photodynamic therapy for the treatment of non\u2010small cell lung cancer","volume":"4","author":"Simone C. B.","year":"2012","journal-title":"J. Thorac. Dis."},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.14338\/IJPT-15-00023.1"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.04.043"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2018.03.019"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr.2017.04.01"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22934"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.35.15_suppl.LBA8507"}],"container-title":["Photochemistry and Photobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fphp.13065","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/php.13065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T04:38:02Z","timestamp":1694666282000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/php.13065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,28]]},"references-count":82,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/php.13065"],"URL":"https:\/\/doi.org\/10.1111\/php.13065","archive":["Portico"],"relation":{},"ISSN":["0031-8655","1751-1097"],"issn-type":[{"value":"0031-8655","type":"print"},{"value":"1751-1097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,28]]},"assertion":[{"value":"2018-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}