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For the efficacy of zinc pyrithione therapeutic cleansers to be assessed accurately, the distribution of particles on the scalp needs to be visualized. Currently, no technique is available which provides the chemical specificity and sensitivity required. Here, we report application of fluorescence\u2010lifetime imaging microscopy (\n                    <jats:styled-content style=\"fixed-case\">FLIM<\/jats:styled-content>\n                    ) for high\u2010contrast mapping of zinc pyrithione distribution on the scalp. Characterization of the zinc pyrithione emission by using both one\u2010photon excitation at five specific wavelengths and two\u2010photon excitation in the range of 740\u2013820 nm revealed its\n                    <jats:styled-content style=\"fixed-case\">FLIM<\/jats:styled-content>\n                    fingerprint\u2014a characteristic short average time\u2010weighted emission lifetime of \u03a4\n                    <jats:sub>ZnPT<\/jats:sub>\n                    = 250 ps. Bandpass\u2010filtering\n                    <jats:styled-content style=\"fixed-case\">FLIM<\/jats:styled-content>\n                    signals at \u03a4\n                    <jats:sub>ZnPT<\/jats:sub>\n                    enabled an efficient discrimination between the zinc pyrithione and major endogenous skin species in comparison with that of the conventional reflectance confocal microscopy. Our findings provide means for\n                    <jats:italic>in vivo<\/jats:italic>\n                    high\u2010sensitivity assaying and high\u2010contrast imaging of zinc pyrithione in biological systems.\n                  <\/jats:p>","DOI":"10.1111\/php.13100","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T04:13:02Z","timestamp":1552968782000},"page":"1142-1150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Optical Characterization of Zinc Pyrithione"],"prefix":"10.1111","volume":"95","author":[{"given":"Lydia","family":"Sandiford","sequence":"first","affiliation":[{"name":"School of Pharmacy and Medical Sciences University of South Australia and Basil Hetzel Institute for Translational Health Research Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2594-9485","authenticated-orcid":false,"given":"Amy M.","family":"Holmes","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Medical Sciences University of South Australia and Basil Hetzel Institute for Translational Health Research Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean E.","family":"Mangion","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Medical Sciences University of South Australia and Basil Hetzel Institute for Translational Health Research Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousuf H.","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Therapeutics Research Centre Diamantina Institute Translational Research Institute University of Queensland Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei V.","family":"Zvyagin","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy ARC Centre of Excellence for Nanoscale BioPhotonics Macquarie University Sydney NSW Australia"},{"name":"Institute of Molecular Medicine Sechenov University Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Roberts","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Medical Sciences University of South Australia and Basil Hetzel Institute for Translational Health Research Adelaide SA Australia"},{"name":"Therapeutics Research Centre Diamantina Institute Translational Research Institute University of Queensland Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,22]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"389","volume-title":"Practical Modern Hair Science","author":"Schwartz J. 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