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A cell line derived from a donor with a human papilloma virus (HPV) infection was more responsive to I\/R but significantly less responsive to PDT than a cell line derived from an HPV\u2010free patient. Cell death after I\/R in the HPV(+) cell line was associated with increased DEVDase activity, a hallmark of apoptosis. The HPV(\u2212) line was considerably less responsive to I\/R, with DEVDase activity greatly reduced, suggesting an impaired apoptotic program. In contrast, the HPV(\u2212) cells were readily killed by PDT when the ER was among the targets for photodamage. While DEVDase activity was enhanced, the death pathway appears to involve paraptosis until the degree of photodamage reached the LD<jats:sub>99<\/jats:sub> range. These data suggest that PDT\u2010induced paraptosis can be a death pathway for cells with an impaired apoptotic program.<\/jats:p>","DOI":"10.1111\/php.13150","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T21:08:54Z","timestamp":1565730534000},"page":"652-657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Effects of <scp>HPV<\/scp> Status on Responsiveness to Ionizing Radiation <i>vs<\/i> Photodynamic Therapy in Head and Neck Cancer Cell lines"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3221-9299","authenticated-orcid":false,"given":"David","family":"Kessel","sequence":"first","affiliation":[{"name":"Department of Pharmacology Wayne State University School of Medicine Detroit MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Jin","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Pathology Wayne State University School of Medicine Detroit MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Rakowski","sequence":"additional","affiliation":[{"name":"Department of Oncology Wayne State University School of Medicine Detroit MI"},{"name":"Division of Radiation Oncology Wayne State University School of Medicine Detroit MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold E.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oncology Wayne State University School of Medicine Detroit MI"},{"name":"Division of Radiation Oncology Wayne State University School of Medicine Detroit MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeong\u2010Reh C.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Wayne State University School of Medicine Detroit MI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn011"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605944"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26500"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpp.331"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1142\/S1088424604000374"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.12857"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.12952"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401465"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1pp05120b"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2012.01106.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.20792"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209336"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/b707953b"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.13066"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.28.17559"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401048"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b05302"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.126"},{"key":"e_1_2_6_20_1","first-page":"4994","article-title":"Mitochondrial alterations in photodynamic therapy\u2010resistant cells","volume":"53","author":"Sharkey S. 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