{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T22:36:18Z","timestamp":1773441378607,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem & Photobiology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"Abstract<\/jats:title>\n \n Human skin is exposed to visible light (\n VL<\/jats:styled-content>\n ; 400\u2013700\u00a0nm) and long\u2010wavelength ultraviolet A1 (\n UVA<\/jats:styled-content>\n 1) radiation (370\u2013400\u00a0nm) after the application of organic broad\u2010spectrum sunscreens. The biologic effects of these wavelengths have been demonstrated; however, a dose\u2013response has not been investigated. Ten subjects with Fitzpatrick skin phototype\n IV<\/jats:styled-content>\n \u2010\n VI<\/jats:styled-content>\n were enrolled. Subjects were irradiated with 2 light sources (80\u2013480\u00a0J\u00a0cm\n \u22122<\/jats:sup>\n ): one comprising\n VL<\/jats:styled-content>\n with less than 0.5%\n UVA<\/jats:styled-content>\n 1 (\n VL<\/jats:styled-content>\n +\n UVA<\/jats:styled-content>\n 1) and the other pure\n VL<\/jats:styled-content>\n . Skin responses were evaluated for 2\u00a0weeks using clinical and spectroscopic assessments. 4\u2010mm punch biopsies were obtained from nonirradiated skin and sites irradiated with 480\u00a0J\u00a0cm\n \u22122<\/jats:sup>\n of\n VL<\/jats:styled-content>\n +\n UVA<\/jats:styled-content>\n 1 and pure\n VL<\/jats:styled-content>\n 24\u00a0h after irradiation. Clinical and spectroscopic assessments demonstrated a robust response at\n VL<\/jats:styled-content>\n +\n UVA<\/jats:styled-content>\n 1 sites compared with pure\n VL<\/jats:styled-content>\n . Histology findings demonstrated a statistically significant increase in the marker of inflammation (\n P<\/jats:italic>\n \u00a0<\u00a00.05) and proliferation (\n P<\/jats:italic>\n \u00a0<\u00a00.05) at the irradiated sites compared with nonirradiated control. Threshold doses of\n VL<\/jats:styled-content>\n +\n UVA<\/jats:styled-content>\n 1 resulting in biologic responses were calculated. Results indicate that approximately 2\u00a0h of sun exposure, which equates to\n VL<\/jats:styled-content>\n +\n UVA<\/jats:styled-content>\n 1 dose (~400\u00a0J\u00a0cm\n \u22122<\/jats:sup>\n ), is capable of inducing inflammation, immediate erythema and delayed tanning. These findings reinforce the need of photoprotection beyond the\n UV<\/jats:styled-content>\n range.\n <\/jats:p>","DOI":"10.1111\/php.13157","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T05:49:01Z","timestamp":1567057741000},"page":"208-214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Long\u2010wavelength Ultraviolet A1 and Visible Light Photoprotection: A Multimodality Assessment of Dose and Response"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2316-6375","authenticated-orcid":false,"given":"Indermeet","family":"Kohli","sequence":"first","affiliation":[{"name":"Department of Dermatology Henry Ford Hospital Detroit MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taylor L.","family":"Braunberger","sequence":"additional","affiliation":[{"name":"Department of Dermatology Henry Ford Hospital Detroit MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda F.","family":"Nahhas","sequence":"additional","affiliation":[{"name":"Department of Dermatology Henry Ford Hospital Detroit MI"},{"name":"Department of Dermatology Beaumont Hospital\u2010Farmington Hills Farmington Hills MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima N.","family":"Mirza","sequence":"additional","affiliation":[{"name":"Yale School of Medicine New Haven CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Mokhtari","sequence":"additional","affiliation":[{"name":"College of Engineering Wayne State University Detroit MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis B.","family":"Lyons","sequence":"additional","affiliation":[{"name":"Department of Dermatology Henry Ford Hospital Detroit MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikiforos","family":"Kollias","sequence":"additional","affiliation":[{"name":"Independent Contractor (Posthumous) Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Ruvolo","sequence":"additional","affiliation":[{"name":"Bayer HealthCare LLC Whippany NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry W.","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Henry Ford Hospital Detroit MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iltefat H.","family":"Hamzavi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Henry Ford Hospital Detroit MI"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12273"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12531710"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15940"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1984.tb03905.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30738-6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.476"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2007.00286.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.95"},{"key":"e_1_2_8_10_1","first-page":"156","volume-title":"The Biological Effects of UVA Radiation","author":"Pathak M.","year":"1986"},{"key":"e_1_2_8_11_1","first-page":"197","article-title":"Quantification of visible light\u2010induced melanogenesis in human skin","volume":"5","author":"Porges S. B.","year":"1988","journal-title":"Photodermatology"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08642.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12105"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.01.044"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14184"},{"key":"e_1_2_8_16_1","first-page":"1","article-title":"Spectral characteristics of visible light\u2010induced pigmentation, and visible light protection factor","author":"Kohli I.","year":"2019","journal-title":"Photodermatol. Photoimmunol. 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