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The purpose of the present study was to assess the distribution and elimination of DVDMS\u20102 in mice bearing hepatoma 22 tumors. DVDMS\u20102 (1, 2 and 4\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>) was injected intravenously into the mice, extracted from biological tissues and quantified using a fluorescence assay. The data obtained were processed with WinNonlin pharmacokinetic software. The fluorescence assay established for DVDMS\u20102 quantification was a rapid, reproducible, sensitive and specific method with good linearity. The pharmacokinetics of DVDMS\u20102 in tumor\u2010bearing mice conformed to a two\u2010compartment model. DVDMS\u20102 accumulated in tumor tissue to a greater extent than adjacent tissues (skin, muscle) and sustained a relatively high\u2010level concentration 12 to 24\u00a0h following administration, which may be the optimal treatment time point. In conclusion, DVDMS\u20102 selectively accumulated in tumor tissue and was eliminated at a rapid rate in tumor\u2010bearing mice, suggesting that DVDMS\u20102 may have few side effects, including skin phototoxicity. The present study established the pharmacokinetic characteristics of DVDMS\u20102, which may be beneficial in future clinical study.<\/jats:p>","DOI":"10.1111\/php.13171","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T21:24:20Z","timestamp":1569965060000},"page":"148-155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pharmacokinetics and Tissue Distribution of DVDMS\u20102 in Tumor\u2010bearing Mice"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5022-7786","authenticated-orcid":false,"given":"Tingting","family":"Li","sequence":"first","affiliation":[{"name":"Cancer Research Center School of Medicine Xiamen University Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Lv","sequence":"additional","affiliation":[{"name":"Xiamen Mental Health Center Xiamen Xianyue Hospital Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Yang","sequence":"additional","affiliation":[{"name":"Cancer Research Center School of Medicine Xiamen University Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xie","sequence":"additional","affiliation":[{"name":"Cancer Research Center School of Medicine Xiamen University Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Liu","sequence":"additional","affiliation":[{"name":"Cancer Research Center School of Medicine Xiamen University Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peilan","family":"Xu","sequence":"additional","affiliation":[{"name":"Cancer Research Center School of Medicine Xiamen University Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanyun","family":"Li","sequence":"additional","affiliation":[{"name":"Cancer Research Center School of Medicine Xiamen University Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Cancer Research Center School of Medicine Xiamen University Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Yang","sequence":"additional","affiliation":[{"name":"Cancer Research Center School of Medicine Xiamen University Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wu","sequence":"additional","affiliation":[{"name":"Cancer Research Center School of Medicine Xiamen University Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghua","family":"Yan","sequence":"additional","affiliation":[{"name":"Cancer Research Center School of Medicine Xiamen University Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanghong","family":"Luo","sequence":"additional","affiliation":[{"name":"Cancer Research Center School of Medicine Xiamen University Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep17485"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2017.3854"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.22465"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21368"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2014.06.001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14989"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.02.016"},{"key":"e_1_2_7_9_1","first-page":"2288","article-title":"Underlying mechanism of the photodynamic activity of hematoporphyrin\u2010induced apoptosis in U87 glioma cells","volume":"41","author":"Yuan S.\u2010X.","year":"2018","journal-title":"Int. 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