{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:57:08Z","timestamp":1791845828798,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T00:00:00Z","timestamp":1575590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 CA087971"],"award-info":[{"award-number":["P01 CA087971"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41 EB015893"],"award-info":[{"award-number":["P41 EB015893"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA154562"],"award-info":[{"award-number":["R01 CA154562"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA236362"],"award-info":[{"award-number":["R01 CA236362"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS060653"],"award-info":[{"award-number":["R01 NS060653"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Explicit dosimetry of treatment light fluence and implicit dosimetry of photosensitizer photobleaching are commonly used methods to guide dose delivery during clinical PDT. Tissue oxygen, however, is not routinely monitored intraoperatively even though it is one of the three major components of treatment. Quantitative information about <jats:italic>in vivo<\/jats:italic> tissue oxygenation during PDT is desirable, because it enables reactive oxygen species explicit dosimetry (ROSED) for prediction of treatment outcome based on PDT\u2010induced changes in tumor oxygen level. Here, we demonstrate ROSED in a clinical setting, Photofrin\u2010mediated pleural photodynamic therapy, by utilizing tumor blood flow information measured by diffuse correlation spectroscopy (DCS). A DCS contact probe was sutured to the pleural cavity wall after surgical resection of pleural mesothelioma tumor to monitor tissue blood flow (blood flow index) during intraoperative PDT treatment. Isotropic detectors were used to measure treatment light fluence and photosensitizer concentration. Blood\u2010flow\u2010derived tumor oxygen concentration, estimated by applying a preclinically determined conversion factor of 1.5\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup> \u03bcMs\u00a0cm<jats:sup>\u22122<\/jats:sup> to the blood flow index, was used in the ROSED model to calculate the total reacted reactive oxygen species [ROS]rx. Seven patients and 12 different pleural sites were assessed and large inter\u2010 and intrapatient heterogeneities in [ROS]rx were observed although an identical light dose of 60\u00a0J\u00a0cm<jats:sup>\u22122<\/jats:sup> was prescribed to all patients.<\/jats:p>","DOI":"10.1111\/php.13176","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T11:19:08Z","timestamp":1573816748000},"page":"340-348","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Reactive Oxygen Species Explicit Dosimetry for Photofrin\u2010mediated Pleural Photodynamic Therapy"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2826-1451","authenticated-orcid":false,"given":"Yi Hong","family":"Ong","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of Pennsylvania Philadelphia PA"},{"name":"Department of Physics and Astronomy University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreaa","family":"Dimofte","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele M.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarod C.","family":"Finlay","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqi","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Singhal","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery Department of Surgery University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith A.","family":"Cengel","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun G.","family":"Yodh","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5499-8377","authenticated-orcid":false,"given":"Theresa M.","family":"Busch","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2842-8984","authenticated-orcid":false,"given":"Timothy C.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.12.889"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20114"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2013.46.1.24"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.21.8.088002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201600121"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.22.12.121701"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-0786"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","unstructured":"Penjweini R. M. M.Kim Y. H.OngandT. C.Zhu(2017)Singlet oxygen explicit dosimetry to predict long\u2010term local tumor control for Photofrin\u2010mediated photodynamic therapy. Proc. SPIE 1004711.","DOI":"10.1117\/12.2251015"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","unstructured":"Sheng T. Y. H.Ong T. M.BuschandT. C.Zhu(2019)Reactive oxygen species explicit dosimetry to predict local tumor control for Photofrin\u2010mediated photodynamic therapy. Proc. SPIE 108600V.","DOI":"10.1117\/12.2508803"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","unstructured":"Penjweini R. M. M.Kim Y. H.OngandT. C.Zhu(2017)Singlet oxygen explicit dosimetry to predict local tumor control for HPPH\u2010mediated photodynamic therapy. Proc. SPIE 1004710.","DOI":"10.1117\/12.2251011"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","unstructured":"Kim M. M. R.Penjweini Y. H.OngandT. C.Zhu(2017)Singlet oxygen explicit dosimetry to predict long\u2010term local tumor control for BPD\u2010mediated photodynamic therapy. Proc. SPIE 100470X.","DOI":"10.1117\/12.2250435"},{"issue":"1","key":"e_1_2_6_13_1","first-page":"7","article-title":"In vivo monitoring of singlet oxygen using delayed chemiluminescence during photodynamic therapy","volume":"12","author":"Wei Y.","year":"2007","journal-title":"J. Biomed. Opt."},{"key":"e_1_2_6_14_1","first-page":"45","volume-title":"Recent Advancements and Applications in Dosimetry","author":"Ong Y. H.","year":"2018"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2011.12.043"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1562\/2006-05-03-IR-891"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.200900101"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","unstructured":"Zhu T. C. J. C.Finlay X.ZhouandJ.Li(2007)Macroscopic modeling of the singlet oxygen production during PDT. Proc. SPIE 642708.","DOI":"10.1117\/12.701387"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","unstructured":"Finlay J. C. T. C.Zhu A.Dimofte J. S.FriedbergandS. M.Hahn(2006)Diffuse reflectance spectra measured in vivo in human tissues during Photofrin\u2010mediated pleural photodynamic therapy. Proc. SPIE 61390O.","DOI":"10.1117\/12.647016"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/aa9874"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.20.3.038001"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002850200135"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-2582"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1364\/JOSAA.16.001651"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1364\/JOSAA.14.000192"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.75.1855"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.5.004053"},{"key":"e_1_2_6_28_1","doi-asserted-by":"crossref","unstructured":"Ong Y. H. M. M.Kim R.Penjweini C. E.Rodriguez A.Dimofte J. C.Finlay T. M.Busch A. G.Yodh K. A.Cengel andT. C.Zhu(2017)Monitoring and assessment of tumor hemodynamics during pleural PDT. Proc. SPIE 100470C.","DOI":"10.1117\/12.2252979"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/33\/12\/008"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15995-1"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.08.071"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.02.009"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.02.062"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.10.5.12616"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2014.09.017"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1364\/OE.24.026261"},{"key":"e_1_2_6_37_1","unstructured":"Ong Y. H. M. M.Kim Z.HuangandT. C.Zhu(2018)Reactive oxygen species explicit dosimetry (ROSED) of a type 1 photosensitizer. Proc. SPIE 104760V."},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.12719"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.2.001969"}],"container-title":["Photochemistry and Photobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/php.13176","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/php.13176","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/php.13176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T21:02:53Z","timestamp":1694034173000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/php.13176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,6]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/php.13176"],"URL":"https:\/\/doi.org\/10.1111\/php.13176","archive":["Portico"],"relation":{},"ISSN":["0031-8655","1751-1097"],"issn-type":[{"value":"0031-8655","type":"print"},{"value":"1751-1097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,6]]},"assertion":[{"value":"2019-09-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}