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The following groups were set up: Ctrl (control group of normal wild\u2010type mice; C57BL\/10); <jats:italic>mdx<\/jats:italic> (untreated <jats:italic>mdx<\/jats:italic> mice); <jats:italic>mdx<\/jats:italic>Pred (<jats:italic>mdx<\/jats:italic> mice treated with prednisolone) and <jats:italic>mdx<\/jats:italic>LA (<jats:italic>mdx<\/jats:italic> mice treated with PBMT). The PBMT was carried out using an Aluminum Gallium Arsenide (AIGaAs; IBRAMED\u00ae laserpulse) diode, 830\u00a0nm wavelength, applied on the dystrophic quadriceps muscle. The <jats:italic>mdx<\/jats:italic>LA group showed a degenerative and regenerative area reduction simultaneously with a MyoD level increase, ROS production and inflammatory marker reduction and up\u2010regulation in the VEGF factor. In addition, PBMT presented similar effects to prednisolone treatment in most of the parameters analyzed. In conclusion, our results indicate that PBMT in the parameters selected attenuated the dystrophic phenotype of <jats:italic>mdx<\/jats:italic> mice, improving skeletal muscle regeneration; reducing the oxidative stress and inflammatory process; and up\u2010regulating the angiogenic marker.<\/jats:p>","DOI":"10.1111\/php.13179","type":"journal-article","created":{"date-parts":[[2019,11,16]],"date-time":"2019-11-16T18:24:18Z","timestamp":1573928658000},"page":"200-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Photobiomodulation Therapy for Attenuating the Dystrophic Phenotype of M<i>dx<\/i> Mice"],"prefix":"10.1111","volume":"96","author":[{"given":"Aline Barbosa","family":"Macedo","sequence":"first","affiliation":[{"name":"Departamento de Biologia Estrutural e Funcional Instituto de Biologia Universidade Estadual de Campinas (UNICAMP) Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Sayuri","family":"Mizobuti","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Estrutural e Funcional Instituto de Biologia Universidade Estadual de Campinas (UNICAMP) Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tulio de Almeida","family":"Hermes","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Estrutural e Funcional Instituto de Biologia Universidade Estadual de Campinas (UNICAMP) Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Dias","family":"M\u00e2ncio","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Estrutural e Funcional Instituto de Biologia Universidade Estadual de Campinas (UNICAMP) Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Pertille","sequence":"additional","affiliation":[{"name":"Graduate Program in Science of Human Movement Universidade Metodista de Piracicaba (UNIMEP) Piracicaba SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa Akemi","family":"Kido","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Estrutural e Funcional Instituto de Biologia Universidade Estadual de Campinas (UNICAMP) Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9ria Helena Alves","family":"Cagnon","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Estrutural e Funcional Instituto de Biologia Universidade Estadual de Campinas (UNICAMP) Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9863-0761","authenticated-orcid":false,"given":"Elaine","family":"Minatel","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Estrutural e Funcional Instituto de Biologia Universidade Estadual de Campinas (UNICAMP) Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,3]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1133","volume-title":"Myology","author":"Engel A. 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