{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T22:19:46Z","timestamp":1785277186273,"version":"3.55.0"},"reference-count":6,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem & Photobiology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"Abstract<\/jats:title>Photochemical internalization (PCI) depends on the delivery of sublethal photodynamic reaction to facilitate the work of a chemotherapeutic agent. We discuss our experience in managing a patient with extensive squamous cell carcinoma of the right face and scalp under the TPCS2a<\/jats:sub>\u2010based bleomycin PCI treatment protocol. In this case, an 84\u2010year\u2010old Caucasian received 0.25\u00a0mg\u00a0kg\u22121<\/jats:sup> of TPCS2a<\/jats:sub> (Amphinex\u00ae<\/jats:sup>, PCI Biotech AS, Oslo, Norway). Surface illumination photochemical internalization was carried out after 4\u00a0days, which was preceded by the chemotherapeutic agent infusion (Bleomycin). After one week from the illumination time, tissue necrosis was evident and tumor shrinkage was most noticeable at day 14 postillumination. Follow\u2010up at 6\u00a0weeks continued to show tissue healing and regeneration with no clinical evidence of recurrence. Multiple surgical biopsies were taken at 1 and 3\u00a0months postillumination and found to be tumor free. PCI\u2019s depth of effect has been very significant with negligible damage to the collateral tissues. This technology has a role in interventional oncology especially when managing challenging cases.<\/jats:p>","DOI":"10.1111\/php.13210","type":"journal-article","created":{"date-parts":[[2020,1,4]],"date-time":"2020-01-04T18:00:20Z","timestamp":1578160820000},"page":"680-683","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Apparent Complete Response of a Treatment Refractory and Recurrent Squamous Cell Carcinoma Lesion to Photochemical Internalization: A Clinical Case Study"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6914-7401","authenticated-orcid":false,"given":"Waseem","family":"Jerjes","sequence":"first","affiliation":[{"name":"UCL Medical School London UK"},{"name":"North End Medical Centre London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaid","family":"Hamdoon","sequence":"additional","affiliation":[{"name":"Unit of OMFS UCL Eastman Dental Institute London UK"},{"name":"College of Dental Medicine University of Sharjah Sharjah UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Radiation Biology Oslo University Hospital Institute of Cancer Research Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"H\u00f8gset","sequence":"additional","affiliation":[{"name":"PCI Biotech AS Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Hopper","sequence":"additional","affiliation":[{"name":"UCL Medical School London UK"},{"name":"Unit of OMFS UCL Eastman Dental Institute London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,17]]},"reference":[{"issue":"6","key":"e_1_2_5_2_1","first-page":"1180","article-title":"Photochemical internalization: a novel technology for delivery of macromolecules into cytosol","volume":"59","author":"Berg K.","year":"1999","journal-title":"Cancer Res."},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2010.07.001"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30224-8"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20010601)92:5<761::AID-IJC1238>3.0.CO;2-4"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2019.06.018"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2008.00477.x"}],"container-title":["Photochemistry and Photobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/php.13210","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/php.13210","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/php.13210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T07:21:56Z","timestamp":1693984916000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/php.13210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,17]]},"references-count":6,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1111\/php.13210"],"URL":"https:\/\/doi.org\/10.1111\/php.13210","archive":["Portico"],"relation":{},"ISSN":["0031-8655","1751-1097"],"issn-type":[{"value":"0031-8655","type":"print"},{"value":"1751-1097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,17]]},"assertion":[{"value":"2019-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}