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This scattering effect affects the response to PDT. Recently, a meta\u2010tetra(hydroxyphenyl)chlorin\u2010mediated PDT study of malignancies in the paranasal sinuses after salvage surgery was initiated. These geometries are complex in shape, with spatially varying optical properties. Therefore, preplanning and <jats:italic>in vivo<\/jats:italic> dosimetry is required to ensure an effective fluence delivered to the tumor. For this purpose, two 3D light distribution models were developed: first, a simple empirical model that directly calculates the fluence rate at the cavity surface using a simple linear function that includes the scatter contribution as function of the light source to surface distance. And second, an analytical model based on Lambert\u2019s cosine law assuming a global diffuse reflectance constant. The models were evaluated by means of three 3D printed optical phantoms and one porcine tissue phantom. Predictive fluence rate distributions of both models are within\u00a0\u00b1\u00a020% accurate and have the potential to determine the optimal source location and light source output power settings.<\/jats:p>","DOI":"10.1111\/php.13216","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T01:52:13Z","timestamp":1578361933000},"page":"405-416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["On the Development of a Light Dosimetry Planning Tool for Photodynamic Therapy in Arbitrary Shaped Cavities: Initial Results"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7815-7118","authenticated-orcid":false,"given":"Th\u00e9r\u00e8se E. 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