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To estimate an acceptable safety dose for human skin in the UV\u2010C range, especially short UV\u2010C, we studied the biological effects of 207, 222 and 235\u00a0nm UV\u2010C using albino hairless mice and evaluated the inflammatory reactions in the skin. To explore an appropriate indicator to evaluate the biological response, we employed determination of the minimal perceptible response dose (MPRD), by which any subtle cutaneous response; erythema, edema and scale could be observed by visual inspection. Erythema was rarely observed, but edema and scale formation were evident for short UV\u2010C wavelengths. The MPRD at 207, 222 and 235\u00a0nm was determined to be\u00a0&gt;\u00a015, 15 and 2.0\u00a0kJ\u00a0m<jats:sup>\u22122<\/jats:sup>, respectively. These values could be thresholds and indicators for possible safety assessments. Our data suggest that the current human exposure limits for short UV\u2010C wavelengths below 254\u00a0nm are overly restrictive and should be reconsidered for future disinfection lamps with short UV\u2010C wavelengths.<\/jats:p>","DOI":"10.1111\/php.13384","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T02:51:55Z","timestamp":1611283915000},"page":"770-777","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Evaluation of Acute Reactions on Mouse Skin Irradiated with 222 and 235 nm UV\u2010C"],"prefix":"10.1111","volume":"97","author":[{"given":"Nozomi","family":"Yamano","sequence":"first","affiliation":[{"name":"Division of Dermatology Department of Internal Related Graduate School of Medicine Kobe University Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2210-6108","authenticated-orcid":false,"given":"Makoto","family":"Kunisada","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Internal Related Graduate School of Medicine Kobe University Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiko","family":"Nishiaki\u2010Sawada","sequence":"additional","affiliation":[{"name":"Ushio Inc. 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