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Sixty patients (smokers\/<jats:italic>n<\/jats:italic>\u00a0=\u00a030, nonsmokers\/<jats:italic>n<\/jats:italic>\u00a0=\u00a030) were enrolled in this parallel\u2010arm clinical study. All patients were divided into two main groups: SRP and PBMT\u00a0+\u00a0SRP. In PMBT\u00a0+\u00a0SRP groups, 7.96\u00a0J\u00a0cm<jats:sup>\u22122<\/jats:sup> energy was applied by 820nm diode laser at baseline and first, second and third weeks after SRP. Periodontal pocket depth (PPD), gingival index (GI), plaque index (PI) and clinical attachment level (CAL) were recorded, and also gingival crevicular fluid (GCF) samples were collected at baseline and 6w after SRP. Total antioxidant capacity (TAOC) and total oxidative status (TOS) in GCF were analyzed. PBMT\u00a0+\u00a0SRP groups showed a statistically significant decrease in PPD and CAL, not in GI and PI compared with SRP alone. There were no statistically significant differences between smokers and nonsmokers in clinical data at six weeks after treatment. Although TAOC levels were increased in PMBT groups, TOS levels were decreased in all groups at the comparison of baseline and 6w after SRP. Adjunct use of 820\u00a0nm diode laser on SRP may improve the clinical parameters in smoker or nonsmoker patient with periodontitis.<\/jats:p>","DOI":"10.1111\/php.13394","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T02:08:44Z","timestamp":1612577324000},"page":"860-864","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Photobiomodulation Therapy by 820 nm Diode Laser on Nonsurgical Periodontal Treatment of Smoker and Nonsmoker Patients: A Single\u2010Blind Parallel Randomized Clinical Trial"],"prefix":"10.1111","volume":"97","author":[{"given":"Hakan","family":"\u00d6zdemir","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry University of Osmangazi Eski\u015fehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3853-2689","authenticated-orcid":false,"given":"Hasan","family":"G\u00fcndo\u011far","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry University of Gaziantep Gaziantep Turkey"},{"name":"Deparment of Medical Biochemistry Faculty of Medicine University of Gaziantep Gaziantep Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysun","family":"Akp\u0131nar","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry University of Uluda\u011f Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.150337"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00823.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2001.2260104.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00902.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2012.11.009"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12229"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12457"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2012.01468.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb01344.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12008"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13164"},{"key":"e_1_2_6_13_1","article-title":"Effectiveness of a nutraceutical agent in the non\u2010surgical periodontal therapy: a randomized, controlled clinical trial","author":"Isola G.","year":"2020","journal-title":"Clin Oral Investig."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-016-1984-z"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13032"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-016-2047-z"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2011.3079"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-007-0477-3"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2010.2771"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-010-0879-5"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100195"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-019-02897-z"},{"key":"e_1_2_6_23_1","first-page":"513","article-title":"Use of diode laser 980 nm as adjunctive therapy in the treatment of chronic periodontitis. 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