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Roemmers","doi-asserted-by":"publisher","award":["Research Grant 2016\u201018"],"award-info":[{"award-number":["Research Grant 2016\u201018"]}],"id":[{"id":"10.13039\/501100006449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007351","name":"Secretaria de Ciencia y Tecnica, Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["20020150200007BA"],"award-info":[{"award-number":["20020150200007BA"]}],"id":[{"id":"10.13039\/501100007351","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007351","name":"Secretaria de Ciencia y Tecnica, Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["20020170100283BA"],"award-info":[{"award-number":["20020170100283BA"]}],"id":[{"id":"10.13039\/501100007351","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    There are limited and controversial studies that address the role of vitamin D (vitD), a vitamin with immunomodulatory effects, in myasthenia gravis (MG), a neuromuscular autoimmune disease. We aimed to assess 25\u2010hydroxy vitamin D (25(OH)D) levels and to evaluate possible associations with the clinical severity and other biomarkers of the disease. Serum levels of 25(OH)D, anti\u2010acetylcholine receptor antibodies and complement factor C5a were measured in MG patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a066) and healthy volunteers (HV) (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a025). Participants were evaluated through questionnaires to determine vitD intake and sunlight exposure. Severity scores were registered for MG patients. We found an 89.4% of MG individuals with nonsufficient levels of vitD, in comparison with 68.0% in the group of HV (OR\u00a0=\u00a03.96;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.024). In addition, there was an inverse correlation between 25(OH)D levels and one of the scores (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.037\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a0\u22120.26, CI\n                    <jats:sub>95<\/jats:sub>\n                    \u00a0=\u00a0\u22120.49 to \u22120.0087). However, when we compared 25(OH)D median serum levels between MG patients and HV, no statistically significant differences have been found. This is the first report of vitD status in a cohort of Argentinean MG patients, where we found that patients are more likely to have nonsufficient levels of vitD compared to healthy people and that patients with more severe disease have lower levels of vitD.\n                  <\/jats:p>","DOI":"10.1111\/php.13432","type":"journal-article","created":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T14:19:36Z","timestamp":1618755576000},"page":"1145-1149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Low Vitamin D Serum Levels in a Cohort of Myasthenia Gravis Patients in Argentina"],"prefix":"10.1111","volume":"97","author":[{"given":"Mariano E.","family":"Justo","sequence":"first","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica Departamento de Microbiolog\u00eda, Inmunolog\u00eda, Biotecnolog\u00eda y Gen\u00e9tica, C\u00e1tedra de Inmunolog\u00eda Universidad de Buenos Aires Buenos Aires Argentina"},{"name":"Instituto de Estudios de la Inmunidad Humoral \u201cProf. Dr. Ricardo A. Margni\u201d (IDEHU) CONICET \u2010 Universidad de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayra","family":"Aldecoa","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Neuroinmunolog\u00eda y Electrofisiolog\u00eda Divisi\u00f3n Neurolog\u00eda Hospital Jos\u00e9 Mar\u00eda Ramos Mej\u00eda Centro Argentino de Neuroinmunolog\u00eda (CADENI) Facultad de Medicina \u2010 Universidad de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana","family":"Cela","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica Departamento de Microbiolog\u00eda, Inmunolog\u00eda, Biotecnolog\u00eda y Gen\u00e9tica, C\u00e1tedra de Inmunolog\u00eda Universidad de Buenos Aires Buenos Aires Argentina"},{"name":"Instituto de Estudios de la Inmunidad Humoral \u201cProf. Dr. Ricardo A. Margni\u201d (IDEHU) CONICET \u2010 Universidad de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Leoni","sequence":"additional","affiliation":[{"name":"Instituto de Estudios de la Inmunidad Humoral \u201cProf. Dr. Ricardo A. Margni\u201d (IDEHU) CONICET \u2010 Universidad de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"Gonz\u00e1lez Maglio","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica Departamento de Microbiolog\u00eda, Inmunolog\u00eda, Biotecnolog\u00eda y Gen\u00e9tica, C\u00e1tedra de Inmunolog\u00eda Universidad de Buenos Aires Buenos Aires Argentina"},{"name":"Instituto de Estudios de la Inmunidad Humoral \u201cProf. Dr. Ricardo A. Margni\u201d (IDEHU) CONICET \u2010 Universidad de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s M.","family":"Villa","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Neuroinmunolog\u00eda y Electrofisiolog\u00eda Divisi\u00f3n Neurolog\u00eda Hospital Jos\u00e9 Mar\u00eda Ramos Mej\u00eda Centro Argentino de Neuroinmunolog\u00eda (CADENI) Facultad de Medicina \u2010 Universidad de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencia","family":"Aguirre","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Neuroinmunolog\u00eda y Electrofisiolog\u00eda Divisi\u00f3n Neurolog\u00eda Hospital Jos\u00e9 Mar\u00eda Ramos Mej\u00eda Centro Argentino de Neuroinmunolog\u00eda (CADENI) Facultad de Medicina \u2010 Universidad de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9371-216X","authenticated-orcid":false,"given":"Mariela L.","family":"Paz","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica Departamento de Microbiolog\u00eda, Inmunolog\u00eda, Biotecnolog\u00eda y Gen\u00e9tica, C\u00e1tedra de Inmunolog\u00eda Universidad de Buenos Aires Buenos Aires Argentina"},{"name":"Instituto de Estudios de la Inmunidad Humoral \u201cProf. Dr. Ricardo A. 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