{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:53:17Z","timestamp":1792633997157,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Photodynamic Therapy (PDT) seems to be a promising method in the treatment of larynx tumor tissues. The aim of the present analysis was the study of photosensitizer penetration of larynx tissue associated with the application of PDT in\u00a0vitro. This study is based on the use of photosensitive compounds Rose Bengal (RB) that selectively accumulate in larynx tissue. The selection of the study group of patients who will undergo surgery in accordance with medical principles was of key importance for the project. Histopathological examination of samples subjected to PDT revealed numerous changes in the morphology of the cancer cells and surrounding tissues. After PDT treatment, the number of tumor cells decreased compared with the cells number before PDT and the arrangement was relatively loose. After PDT with RB the nuclei morphology was incomplete and fragmented. The effects of the applied PDT of larynx in\u00a0vitro were assessed under an optical microscope. The future directions in larynx tumor PDT with the use of upconversion nanoparticles (UPCNP) is also discussed.<\/jats:p>","DOI":"10.1111\/php.13488","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T15:31:59Z","timestamp":1626795119000},"page":"1445-1452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Rose Bengal and Future Directions in Larynx Tumor Photodynamic Therapy<sup>\u2020<\/sup>"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5557-5464","authenticated-orcid":false,"given":"Dorota","family":"Bartusik\u2010Aebisher","sequence":"first","affiliation":[{"name":"Medical College of The University of Rzeszow University of Rzesz\u00f3w Rzesz\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0141ukasz","family":"O\u017c\u00f3g","sequence":"additional","affiliation":[{"name":"Medical College of The University of Rzeszow University of Rzesz\u00f3w Rzesz\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Domka","sequence":"additional","affiliation":[{"name":"Medical College of The University of Rzeszow University of Rzesz\u00f3w Rzesz\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2661-6570","authenticated-orcid":false,"given":"David","family":"Aebisher","sequence":"additional","affiliation":[{"name":"Medical College of The University of Rzeszow University of Rzesz\u00f3w Rzesz\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(81)90024-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000-9604.2020.01.03"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02907735"},{"issue":"7","key":"e_1_2_7_5_1","first-page":"1757","article-title":"Reliability of toluidine blue vital staining in detection of potentially malignant oral lesions\u2013time to reconsider","volume":"12","author":"Upadhyay J.","year":"2011","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cm.21655"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2014.3863"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2011.02042.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22308"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105778"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22467"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2009.04.024"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2004.09.002"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1988.tb02760.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-6030(99)00042-8"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20368"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.555965"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/b417319h"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199404000-00001"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199809000-00001"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2007.00153.x"},{"issue":"3","key":"e_1_2_7_22_1","first-page":"249","article-title":"Photodynamic therapy in management of head and neck cancers and precancerous lesions","volume":"83","author":"Kulapaditharom B.","year":"2000","journal-title":"J. Med. Assoc. Thai."},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2009.98"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.08.049"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-7-113"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14029"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13353"},{"issue":"4","key":"e_1_2_7_28_1","first-page":"138","article-title":"Photodynamic therapy in dermatology","volume":"4","author":"Kwa\u015bny M.","year":"2018","journal-title":"Forum Dermatologicum"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-58813-6"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.6b00068"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja511420n"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b01784"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2010.09.002"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2009.11.004"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp200590y"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2933"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn304872n"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.5284"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac500060c"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn503450t"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn506107c"}],"container-title":["Photochemistry and Photobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/php.13488","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/php.13488","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/php.13488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T03:06:53Z","timestamp":1692846413000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/php.13488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,29]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/php.13488"],"URL":"https:\/\/doi.org\/10.1111\/php.13488","archive":["Portico"],"relation":{},"ISSN":["0031-8655","1751-1097"],"issn-type":[{"value":"0031-8655","type":"print"},{"value":"1751-1097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,29]]},"assertion":[{"value":"2021-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}