{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:18:30Z","timestamp":1787015910277,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010558","name":"Beiersdorf","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010558","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The role of topical antioxidants (AOs) on visible light plus ultraviolet A1 (VL+UVA1)\u2010induced skin changes were evaluated. Twenty subjects with skin phototypes (SPTs) I\u2010VI had placebo and concentrations of an AO blend applied to their back (AO 0.5%, 1.0% and 2.0%). Treated and control sites were irradiated with VL+UVA1. Colorimetric and diffuse reflectance spectroscopy (DRS) assessments were performed immediately, 24\u2009h and 7\u2009days after irradiation. Subjects with SPT I\u2010III had erythema that faded within 24\u2009h, while SPT IV\u2010VI had persistent pigmentation. SPT I\u2010III demonstrated significantly less erythema at the 2% AO site while SPT IV\u2010VI demonstrated significantly less immediate pigmentation at 2% AO site and less pigmentation (approaching significance,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.07) on day 7 compared with control. Immunohistochemistry from biopsies of 2% AO and placebo at 24\u2009h did not demonstrate a significant change in COX\u20102 or MART\u20101 for any SPT. There was a decrease in cyclin D1 for SPT IV\u2010VI which was approaching significance (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.06) but not for SPT I\u2010III. The results indicate that topical AO inhibits erythema in SPT I\u2010III and reduces pigmentation in SPT IV\u2010VI caused by VL+UVA1. AO may help prevent worsening of pigmentary disorders and should be incorporated into photoprotection.\n                  <\/jats:p>","DOI":"10.1111\/php.13525","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T06:44:23Z","timestamp":1632293063000},"page":"455-460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Mitigating Visible Light and Long Wavelength UVA1\u2010induced Effects with Topical Antioxidants"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0799-5680","authenticated-orcid":false,"given":"Alexis B.","family":"Lyons","sequence":"first","affiliation":[{"name":"Photomedicine and Photobiology Unit Department of Dermatology Henry Ford Hospital Detroit MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raheel","family":"Zubair","sequence":"additional","affiliation":[{"name":"Graduate Medical Education Broward Health 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