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In this study, phthalonitrile and metallophthalocyanine compounds linked by benzenesulfonic acid groups have been prepared. Antimicrobial behaviors of those compounds were investigated by performing disk diffusion and photodynamic assays on gram\u2010positive and negative bacteria. Indium phthalocyanine (InClPc) (3) showed inhibition activity against <jats:italic>B. cereus<\/jats:italic>, <jats:italic>B. subtilis<\/jats:italic> and <jats:italic>S. aureus<\/jats:italic> with disk diffusion assay. Also, gallium and indium phthalocyanines (2 and 3) exhibited inhibitory activity on both gram\u2010positive and \u2010negative microorganisms after light activation. Increasing the inhibitor concentration and light exposure time increased the inhibition activity for both molecules. GaClPc (2) demonstrated the maximum reducing power capacity among studied compounds, and CoPc (4) showed even better DPPH radical scavenging ability than the standard molecule Trolox at 2000\u2009\u00b5g\u2009mL<jats:sup>\u22121<\/jats:sup> concentration. The dose\u2010dependent effect of compounds on cytotoxicity was studied against cancer cells PANC\u20101, MDA\u2010MB\u2010231, HepG2, A549, HeLa, CaCo\u20102 and non\u2010tumorigenic cells HEK\u2010293. All compounds showed no significant cytotoxic effect on any cell line up to the highest treated concentration at 50\u2009\u00b5g\u2009mL<jats:sup>\u22121<\/jats:sup>. However, all phthalocyanines had significant nitric oxide inhibition activity, and only in copper phthalocyanine (CuPc) (5), the MTT IC<jats:sub>50<\/jats:sub> value was reached on LPS\u2010activated RAW 264.7 macrophage cells. The lowest inducible nitric oxide synthase (iNOS) IC<jats:sub>50<\/jats:sub> values were defined as 6\u2009\u00b1\u20091\u2009\u03bcg\u2009mL<jats:sup>\u22121<\/jats:sup> and 7\u2009\u00b1\u20090.5\u2009\u03bcg\u2009mL<jats:sup>\u22121<\/jats:sup> for CuPc (5) and InClPc (3), respectively.<\/jats:p>","DOI":"10.1111\/php.13558","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T16:11:57Z","timestamp":1636387917000},"page":"907-915","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Assessment of <i>in\u00a0vitro<\/i> Cytotoxic, iNOS, Antioxidant and Photodynamic Antimicrobial Activities of Water\u2010soluble Sulfonated Phthalocyanines"],"prefix":"10.1111","volume":"98","author":[{"given":"Mustafa","family":"Akin","sequence":"first","affiliation":[{"name":"Petroya\u011f and Kimyasallar San. Tic. 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