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Photobiol<\/jats:italic>. 2022). The collaborative team utilized computational approaches to investigate the influence of electron\u2010withdrawing groups at the 10\u2032 position of tetramethylrhodamine (TMR). Leveraging this information, the team was able to extend the emission of the TMR scaffold into the shortwave\u2010infrared region (SWIR, 1000\u20132500\u2009nm) by incorporation of a ketone functional group at the 10\u2032 position (Daly <jats:italic>et\u00a0al<\/jats:italic>. <jats:italic>Photochem. Photobiol<\/jats:italic>. 2022). This work provides the first example of a TMR derivative with peak SWIR emission (<jats:italic>\u03bb<\/jats:italic><jats:sub>abs<\/jats:sub>: 862\u2009nm, <jats:italic>\u03bb<\/jats:italic><jats:sub>em<\/jats:sub>: 1058\u2009nm). The authors utilize the ketone rhodamine scaffold to generate fluorogenic, pH\u2010responsive reporters. This work demonstrates the potential of the classic xanthene scaffold for use as a SWIR reporter, an important step in the ultimate expansion of the repertoire of small\u2010molecule organic fluorophore scaffolds available for deep\u2010tissue imaging applications.<\/jats:p>","DOI":"10.1111\/php.13578","type":"journal-article","created":{"date-parts":[[2021,12,25]],"date-time":"2021-12-25T11:41:05Z","timestamp":1640432465000},"page":"400-403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Heteroatom\u2010Substituted Xanthene Fluorophores Enter the Shortwave\u2010Infrared Region<sup>\u2020<\/sup>"],"prefix":"10.1111","volume":"98","author":[{"given":"Frederik","family":"Br\u00f8ndsted","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Virginia Charlottesville VA 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