{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T08:58:38Z","timestamp":1759481918071,"version":"3.40.5"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773696\uff1b","82073955"],"award-info":[{"award-number":["81773696\uff1b","82073955"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Blue light is a crucial environmental cue for fungi. Hypocrellin A (HA) is a photoactive perylenequinone from <jats:italic>Shiraia<\/jats:italic> with strong antimicrobial and anticancer properties. In this study, effects of the illumination of blue\u2013light\u2010emitting diode (LED) at 470\u2009nm on <jats:italic>Shiraia<\/jats:italic> sp. S8 were investigated. Blue light at 50\u2013200\u2009lx and 4\u20136\u2009h day<jats:sup>\u22121<\/jats:sup> could enhance HA content in the mycelia, but suppress it at 300\u2013400\u2009lx or with longer exposure (8\u201324\u2009h day<jats:sup>\u22121<\/jats:sup>). The intermittent blue light (6\u2009h day<jats:sup>\u22121<\/jats:sup>) at 200\u2009lx not only enhanced the fungal conidiation but also stimulated HA production without any growth retardation. The generation of fungal reactive oxygen species was induced to upregulate HA biosynthetic gene expressions. When the culture was maintained under the intermittent blue light for 8\u2009days, HA production reached 242.76\u2009mg L<jats:sup>\u22121<\/jats:sup>, 2.27\u2010fold of the dark control. On the other hand, both the degradation of HA and downregulation of HA biosynthetic genes occurred under long exposure time (8\u201324\u2009h day<jats:sup>\u22121<\/jats:sup>), leading to the suppression of HA production. These results provide a basis for understanding the regulation of blue light on the biosynthesis of fungal photoactivated perylenequinones, and the application of a novel light elicitation to <jats:italic>Shiraia<\/jats:italic> mycelium cultures for enhanced HA production.<\/jats:p>","DOI":"10.1111\/php.13640","type":"journal-article","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T13:40:29Z","timestamp":1651671629000},"page":"1343-1354","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Blue Light on Hypocrellin A Production in <i>Shiraia<\/i> Mycelium Cultures"],"prefix":"10.1111","volume":"98","author":[{"given":"Xin Ping","family":"Li","sequence":"first","affiliation":[{"name":"College of Pharmaceutical Sciences Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong Yao","family":"Ji","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen Juan","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen Hao","family":"Shen","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3095-7394","authenticated-orcid":false,"given":"Jian Wen","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201200184"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1994.tb05100.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo901386d"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2017.03.020"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jre.2018.10.010"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-017-1965-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2018.04.004"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.13038"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-018-1529-8"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/aem.38.6.1074-1077.1979"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2010.12.022"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053616"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11694\u2010019\u201000040\u20108"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cropro.2020.105272"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1139\/m95-136"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2006.01.002"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0854.2002.30502.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02508"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.adgen.2016.08.002"},{"key":"e_1_2_7_22_1","first-page":"17","article-title":"Developing characteristics and relationships of Shiraia bambusicola with bamboo","volume":"34","author":"Liu Y. X.","year":"2012","journal-title":"J. Sci. Technol."},{"key":"e_1_2_7_23_1","first-page":"279","article-title":"Studies on systematics, biology and bioactive substance of Shiraia bambusicola","volume":"22","author":"Li X. M.","year":"2009","journal-title":"Forest Res."},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cplett.2004.07.124"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1990.tb01807.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.5080"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-phyto-080417-045931"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(96)07405-2"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.9.2736"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.5.3.499-506.2006"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-005-0209-2"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12934-019-1170-5"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12934-021-01637-9"},{"key":"e_1_2_7_34_1","first-page":"34","article-title":"Environmental factors affecting development of Aspergillus nidulans","volume":"41","author":"Han K. H.","year":"2003","journal-title":"J. Microbiol."},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0109-x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/791963"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c03389"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.funbio.2014.09.002"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21091118"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2010.03.001"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2016.07.013"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2008.08.004"},{"key":"e_1_2_7_43_1","first-page":"357","article-title":"Isolation, screening and confirmative identification of high hypocrellin A\u2010producing Shiraia bambusicola isolates","volume":"37","author":"Liu Y. X.","year":"2009","journal-title":"Khon Kaen Agr. J."},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbt.2011.02.001"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22030385"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins4121535"}],"container-title":["Photochemistry and Photobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/php.13640","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/php.13640","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/php.13640","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T08:01:44Z","timestamp":1692604904000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/php.13640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,17]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/php.13640"],"URL":"https:\/\/doi.org\/10.1111\/php.13640","archive":["Portico"],"relation":{},"ISSN":["0031-8655","1751-1097"],"issn-type":[{"type":"print","value":"0031-8655"},{"type":"electronic","value":"1751-1097"}],"subject":[],"published":{"date-parts":[[2022,5,17]]},"assertion":[{"value":"2022-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}