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Recently, there has been a trend of replacing broad\u2010band UVB (BB\u2010UVB) units with narrow\u2010band UVB (NB\u2010UVB), as studies have demonstrated that NB\u2010UVB is more efficacious in the treatment of psoriasis. The purpose of this study is to evaluate the biological effects and transcriptome changes induced by light\u2010emitting diode\u2010based NB\u2010UVB (NB\u2010UVB LED) phototherapy. Cell viability and the cell migration ability were significantly decreased posttreatment, as well as apoptosis and ROS levels were remarkably increased. NB\u2010UVB\u2010induced S phase arrest was observed 12\u2009h postirradiation. Bioinformatics analysis of transcriptome sequencing data revealed that NB\u2010UVB LED irradiation induced dose\u2010depended changes in multiple key signaling pathways, such as PI3K and cytoskeletal\u2010related pathways. The depolymerization of cytoskeleton induced by NB\u2010UVB was observed 24\u2009h posttreatment. In addition, the expression levels of cytoskeleton\u2010related proteins FN1, ITGB4, ITGA1, RAC2 and DOCK1 decreased significantly 12\u2009h after irradiation. Our results indicated that NB\u2010UVB LED may serve as a novel option for the development of NB\u2010UVB phototherapy devices.<\/jats:p>","DOI":"10.1111\/php.13643","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T06:30:12Z","timestamp":1652250612000},"page":"1379-1389","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of Biological Effects and Transcriptome Changes Induced by <scp>LED<\/scp>\u2010Based Narrow\u2010Band <scp>UVB<\/scp> Phototherapy"],"prefix":"10.1111","volume":"98","author":[{"given":"Xinfeng","family":"Liu","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine University of Science and Technology of China  Hefei China"},{"name":"Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaiyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeyang","family":"Li","sequence":"additional","affiliation":[{"name":"Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqiang","family":"Duan","sequence":"additional","affiliation":[{"name":"Shanxi Academy of Advanced Research and Innovation  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xibin","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine University of Science and Technology of China  Hefei China"},{"name":"Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine University of Science and Technology of China  Hefei China"},{"name":"Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linyu","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine University of Science and Technology of China  Hefei China"},{"name":"Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Gong","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine University of Science and Technology of China  Hefei China"},{"name":"Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8569-9134","authenticated-orcid":false,"given":"Kun","family":"Han","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine University of Science and Technology of China  Hefei China"},{"name":"Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15102063"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2014.03.003"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.339"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2016.1213631"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4006"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00184"},{"key":"e_1_2_6_8_1","first-page":"872","article-title":"Clinical application of ultraviolet therapy in dermatology: An expert consensus statement","volume":"52","author":"Chinese Association of Rehabilitation Dermatology; Skin Phototherapy Group, Committee on Skin Disease and Cosmetic Dermatology, China Association of Medical Equipment","year":"2019","journal-title":"Chinese J. 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