{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:26:04Z","timestamp":1791487564859,"version":"4.3.4"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000003","name":"Boeing","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000003","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["5R42AI125006"],"award-info":[{"award-number":["5R42AI125006"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Far\u2010UVC radiation, typically defined as 200\u2013235\u2009nm, has similar or greater anti\u2010microbial efficacy compared with conventional 254\u2010nm germicidal radiation. In addition, biophysical considerations of the interaction of far\u2010UVC with tissue, as well as multiple short\u2010term safety studies in animal models and humans, suggest that far\u2010UVC exposure may be safe for skin and eye tissue. Nevertheless, the potential for skin cancer after chronic long\u2010term exposure to far\u2010UVC has not been studied. Here, we assessed far\u2010UVC induced carcinogenic skin changes and other pathological dermal abnormalities in 96 SKH\u20101 hairless mice of both sexes that were exposed to average daily dorsal skin doses of 400, 130 or 55\u2009mJ\u2009cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    of 222\u2009nm far\u2010UVC radiation for 66\u2009weeks, 5\u2009days per week, 8\u2009h per day, as well as similarly\u2010treated unexposed controls. No evidence for increased skin cancer, abnormal skin growths or incidental skin pathology findings was observed in the far\u2010UVC\u2010exposed mice. In addition, there were no significant changes in morbidity or mortality. The findings from this study support the long\u2010term safety of long\u2010term chronic exposure to far\u2010UVC radiation, and therefore its potential suitability as a practical anti\u2010microbial approach to reduce airborne viral and bacterial loads in occupied indoor settings.\n                  <\/jats:p>","DOI":"10.1111\/php.13656","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T01:30:05Z","timestamp":1653528605000},"page":"168-175","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["No Evidence of Induced Skin Cancer or Other Skin Abnormalities after Long\u2010Term (66\u2009week) Chronic Exposure to 222\u2010nm\n                    <scp>Far\u2010UVC<\/scp>\n                    Radiation"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2784-496X","authenticated-orcid":false,"given":"David","family":"Welch","sequence":"first","affiliation":[{"name":"Center for Radiological Research Columbia University Irving Medical Center  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman J.","family":"Kleiman","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, Mailman School of Public Health Columbia University Irving Medical Center  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Arden","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, Mailman School of Public Health Columbia University Irving Medical Center  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine 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