{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:43:10Z","timestamp":1791549790717,"version":"4.3.4"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T00:00:00Z","timestamp":1654992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ultraviolet (UV) radiation from sunlight is a major risk factor for many cutaneous pathologies including skin aging and cancers. Despite decades of research, the different responses to UVA and UVB in human keratinocytes have not been systemically investigated. Here, we performed multi\u2010omics to characterize the common and different changes in gene transcription and protein expression after exposure to UVB and UVA, respectively. Keratinocyte cells, treated with or without UV, were analyzed by TMT\u2010labeled MS\/MS spectra and RNA\u2010sequencing. A common set of genes\/proteins was found to be impacted by both UVA and UVB and the other differential genes\/proteins showed wavelength specificity. The common set of genes\/proteins were mainly involved in keratinization, lipid metabolic processes and stimulus response. The UVB specifically responsive genes\/proteins were mainly related to RNA processing, gene silencing regulation and cytoskeleton organization. The UVA specifically responsive genes\/proteins were mainly involved in vesicle\u2010mediated transport and oxygen\u2010containing compound response. Meanwhile, the hub differential genes\/proteins in each set were identified by protein\u2013protein interaction networks and cluster analysis. This work provided a global view of the similar and differential molecular mechanisms of UVB\u2010 and UVA\u2010induced cell damage in keratinocytes, which would be beneficial for further studies in the prevention or treatment of UV\u2010related pathologies.<\/jats:p>","DOI":"10.1111\/php.13658","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T08:09:08Z","timestamp":1653984548000},"page":"137-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Combined Transcriptomic and Proteomic Analyses Reveal the Different Responses to <scp>UVA<\/scp> and <scp>UVB<\/scp> Radiation in Human Keratinocytes"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4092-5329","authenticated-orcid":false,"given":"Qinqin","family":"Zhao","sequence":"first","affiliation":[{"name":"Characteristic Plants Research and Development Center Botanee Research Institute, Shanghai Jiyan Bio\u2010Pharmaceutical Development Co., Ltd.  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyue","family":"Chen","sequence":"additional","affiliation":[{"name":"Characteristic Plants Research and Development Center Botanee Research Institute, Shanghai Jiyan Bio\u2010Pharmaceutical Development Co., Ltd.  Shanghai China"},{"name":"Yunnan Characteristic Plant Extraction Laboratory Yunnan Yunke Characteristic Plant Extraction Laboratory Co., Ltd.  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6469-218X","authenticated-orcid":false,"given":"Liping","family":"Qu","sequence":"additional","affiliation":[{"name":"Characteristic Plants Research and Development Center Botanee Research Institute, Shanghai Jiyan Bio\u2010Pharmaceutical Development Co., Ltd.  Shanghai China"},{"name":"Yunnan Characteristic Plant Extraction Laboratory Yunnan Yunke Characteristic Plant Extraction Laboratory Co., Ltd.  Kunming China"},{"name":"Yunnan Botanee Bio\u2010technology Group Co., Ltd.  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42646"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12679"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06412.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2003.09.009"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2004.07.019"},{"key":"e_1_2_6_7_1","first-page":"515","article-title":"Mechanisms involved in ultraviolet light\u2010induced immunosuppression","volume":"13","author":"Aubin F.","year":"2003","journal-title":"Eur. J. 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