{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:44:26Z","timestamp":1790117066684,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA243164"],"award-info":[{"award-number":["R01CA243164"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EB017270"],"award-info":[{"award-number":["R01EB017270"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Porphyrin\u2010phospholipid (PoP) liposomes loaded with Doxorubicin (Dox) have been demonstrated to be an efficient vehicle for chemophototherapy (CPT). Multidrug resistance (MDR) of cancer cells is a problematic phenomenon in which tumor cells develop resistance to chemotherapy. Herein, we report that Dox\u2010resistant tumor cells can be ablated using our previously described formulation termed long\u2010circulating Dox loaded in PoP liposomes (LC\u2010Dox\u2010PoP), which is a PEGylated formulation containing 2\u2009mol. % of the PoP photosensitizer. <jats:italic>In vitro<\/jats:italic> studies using free Dox and LC\u2010Dox\u2010PoP showed that human ovarian carcinoma A2780 cells were more susceptible to Dox compared to the corresponding Dox\u2010resistant A2780\u2010R cells. When CPT was applied with LC\u2010Dox\u2010PoP liposomes, effective killing of both nonresistant and resistant A2780 cell lines was observed. An <jats:italic>in\u00a0vivo<\/jats:italic> study to assess the efficiency of LC\u2010Dox\u2010PoP showed effective tumor shrinkage and prolonged survival of athymic nude mice bearing subcutaneous Dox\u2010resistant A2780\u2010R tumor xenografts when they were irradiated with a red laser. Biodistribution analysis demonstrated enhanced tumoral drug uptake in Dox\u2010resistant tumors with CPT, suggesting that increased drug delivery was sufficient to induce ablation of resistant tumor cells.<\/jats:p>","DOI":"10.1111\/php.13677","type":"journal-article","created":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T04:54:12Z","timestamp":1658033652000},"page":"844-849","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chemophototherapeutic Ablation of <scp>Doxorubicin\u2010Resistant<\/scp> Human Ovarian Tumor Cells<sup>\u2020<\/sup>"],"prefix":"10.1111","volume":"99","author":[{"given":"Sanjana","family":"Ghosh","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering University at Buffalo, State University of New York  Buffalo NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Upendra","family":"Chitgupi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University at Buffalo, State University of New York  Buffalo NY"},{"name":"Nektar Therapeutics, Formulations Group  San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulas","family":"Sunar","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Industrial &amp; Human Factors Engineering Wright State University  Dayton OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9052-884X","authenticated-orcid":false,"given":"Jonathan F.","family":"Lovell","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University at Buffalo, State University of New York  Buffalo NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2018.07.010"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-019-0718-9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2006.03.011"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-80-2-249"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.03.020"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.03.013"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002800051053"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1985.3.3.311"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-018-0005-8"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201600106"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23040907"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119341"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.13002"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2010.09.002"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10032"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.10.027"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.01.030"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4546"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.8b00052"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.1c00138"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.990100415"},{"issue":"21","key":"e_1_2_6_23_1","first-page":"5225","article-title":"Cross\u2010resistance to diverse drugs is associated with primary cisplatin resistance in ovarian cancer cell lines","volume":"53","author":"Hamaguchi K.","year":"1993","journal-title":"Cancer Res."},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201503966"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b06578"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-18-0549"},{"issue":"23","key":"e_1_2_6_27_1","first-page":"8126","article-title":"Photodynamic therapy: A means to enhanced drug delivery to tumors","volume":"63","author":"Snyder J. W.","year":"2003","journal-title":"Cancer Res."}],"container-title":["Photochemistry and Photobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/php.13677","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/php.13677","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/php.13677","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T17:54:59Z","timestamp":1692640499000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/php.13677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,2]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/php.13677"],"URL":"https:\/\/doi.org\/10.1111\/php.13677","archive":["Portico"],"relation":{},"ISSN":["0031-8655","1751-1097"],"issn-type":[{"value":"0031-8655","type":"print"},{"value":"1751-1097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,2]]},"assertion":[{"value":"2022-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}