{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T11:15:03Z","timestamp":1767093303235,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003653","name":"Korea National Institute of Health","doi-asserted-by":"publisher","award":["P01 CA 87971","R01 EB 028778\u201001A1","R01 R01EB32821\u201001"],"award-info":[{"award-number":["P01 CA 87971","R01 EB 028778\u201001A1","R01 R01EB32821\u201001"]}],"id":[{"id":"10.13039\/501100003653","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Photodynamic therapy (PDT) has been used to treat malignant pleural mesothelioma. Current practice involves delivering light to a prescribed light fluence with a point source, monitored by eight isotropic detectors inside the pleural cavity. An infrared (IR) navigation system was used to track the location of the point source throughout the treatment. The recorded data were used to reconstruct the pleural cavity and calculate the light fluence to the whole cavity. An automatic algorithm was developed recently to calculate the detector positions based on recorded data within an hour. This algorithm was applied to patient case studies and the calculated results were compared to the measured positions, with an average difference of 2.5\u2009cm. Calculated light fluence at calculated positions were compared to measured values. The differences between the calculated and measured light fluence were within 14% for all cases, with a fixed scattering constant and a dual correction method. Fluence\u2010surface histogram (FSH) was calculated for photofrin\u2010mediated PDT to be able to cover 80% of pleural surface area to 50\u2009J\u2009cm<jats:sup>\u22122<\/jats:sup>(83.3% of 60\u2009J\u2009cm<jats:sup>\u22122<\/jats:sup>). The study demonstrates that it will be possible to eliminate the manual measurement of the detector positions, reducing the patient's time under anesthesia.<\/jats:p>","DOI":"10.1111\/php.13697","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T08:19:22Z","timestamp":1661242762000},"page":"814-825","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of Detector Position and Light Fluence Distribution Using an Infrared Navigation System during Pleural Photodynamic Therapy<sup>\u2020<\/sup>"],"prefix":"10.1111","volume":"99","author":[{"given":"Hongjing","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of Pennsylvania  Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele M.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Pennsylvania  Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2826-1451","authenticated-orcid":false,"given":"Yi Hong","family":"Ong","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Pennsylvania  Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreea","family":"Dimoft","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Pennsylvania  Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil","family":"Singhal","sequence":"additional","affiliation":[{"name":"Department of Surgery Perelman School of Medicine at the University of Pennsylvania  Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5499-8377","authenticated-orcid":false,"given":"Theresa M.","family":"Busch","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Pennsylvania  Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6960-5882","authenticated-orcid":false,"given":"Keith A.","family":"Cengel","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Pennsylvania  Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2842-8984","authenticated-orcid":false,"given":"Timothy C.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Pennsylvania  Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.11.136"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.8523"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/107327480601300402"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1586\/17476348.2016.1171147"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semtcvs.2009.07.001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.02.009"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.08.071"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20114"},{"key":"e_1_2_8_10_1","first-page":"63","article-title":"Photodynamic therapy for the treatment of non\u2010small cell lung cancer","volume":"4","author":"Simone C. 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