{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T02:07:20Z","timestamp":1778551640596,"version":"3.51.4"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T00:00:00Z","timestamp":1665532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI132638"],"award-info":[{"award-number":["R01 AI132638"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI141439"],"award-info":[{"award-number":["R01 AI141439"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hyphae formation is a key step for fungal penetration into epithelial cells and escaping from macrophages or neutrophils. We found that 405\u2009nm light\u2010induced catalase deactivation results in the inhibition of hyphae growth in <jats:italic>Candida albicans<\/jats:italic>. The treatment is capable of inhibiting hyphae growth across multiple hyphae\u2010producing <jats:italic>Candida<\/jats:italic> species. Metabolic studies on light\u2010treated <jats:italic>C.\u2009albicans<\/jats:italic> reveal that light treatment results in a strong reduction in both lipid and protein metabolism. A significant decrease in unsaturated and saturated fatty acids was detected through mass spectroscopy, indicating that the suppression of hyphae through light\u2010induced catalase deactivation may occur through inhibition of lipid metabolism. Initial <jats:italic>in\u2009vivo<\/jats:italic> tests indicate that blue light treatment can suppress the hyphae forming capabilities of <jats:italic>C.\u2009albicans<\/jats:italic> within murine abrasion infections. Together, these findings open new avenues for the treatment of <jats:italic>Candida<\/jats:italic> fungal infections by targeting their dimorphism.<\/jats:p>","DOI":"10.1111\/php.13719","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T07:10:25Z","timestamp":1663571425000},"page":"936-946","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Blue Light Deactivation of Catalase Suppresses <i>Candida Hyphae<\/i> Development Through Lipogenesis Inhibition"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3742-773X","authenticated-orcid":false,"given":"Sebastian","family":"Jusuf","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Boston University  Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8959-3978","authenticated-orcid":false,"given":"Yuewei","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Boston University  Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Electrical &amp; Computer Engineering Boston University  Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie J.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Massachusetts General Hospital  Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Viens","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Massachusetts General Hospital  Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8892-8695","authenticated-orcid":false,"given":"Michael K.","family":"Mansour","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Massachusetts General Hospital  Boston MA"},{"name":"Harvard Medical School  Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5607-6683","authenticated-orcid":false,"given":"Ji\u2010Xin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Boston University  Boston MA"},{"name":"Department of Electrical &amp; Computer Engineering Boston University  Boston MA"},{"name":"Photonics Center Boston University  Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof3040057"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.15698\/mic2020.06.718"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003550"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/655683"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2017.06.021"},{"key":"e_1_2_8_7_1","first-page":"1","article-title":"Biofilms in dermatology","volume":"17","author":"Nusbaum A. G.","year":"2012","journal-title":"Skin Therapy Lett."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2007.tb01313.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.12.4.501"},{"key":"e_1_2_8_10_1","first-page":"2173","article-title":"Azole antifungal resistance in Candida albicans and emerging non\u2010albicans Candida species","volume":"7","author":"Whaley S. G.","year":"2016","journal-title":"Front. Microbiol."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008921"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.5.1953-1961.1998"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(01)02094-7"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja9018572"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12447"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2003.tb03376.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2004.05.008"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2636"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00616.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00629"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/13693780500107554"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.3.3.675-684.2004"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3314\/jjmm1960.23.159"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2008.00006.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004030050484"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006763"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00105-08"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114531"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)61523-1"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-003-0446-y"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233718795744"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2016.1155015"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202104384"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005644"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiab009"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202001452"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18040708"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5266(03)00039-6"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymben.2017.04.008"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-061009-102430"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2008.00877.x"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00381-06"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.10.3101-3108.1991"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00437a001"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b08012"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2005.04.006"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-020711-074942"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-01-551473"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00659.x"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0213063"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15834-4"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms5020032"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/517529"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/ftw018"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1586\/eri.11.152"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S118892"}],"container-title":["Photochemistry and Photobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/php.13719","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/php.13719","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/php.13719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T14:25:23Z","timestamp":1692455123000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/php.13719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,12]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/php.13719"],"URL":"https:\/\/doi.org\/10.1111\/php.13719","archive":["Portico"],"relation":{},"ISSN":["0031-8655","1751-1097"],"issn-type":[{"value":"0031-8655","type":"print"},{"value":"1751-1097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,12]]},"assertion":[{"value":"2022-06-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}