{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:18:56Z","timestamp":1787015936807,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,15]],"date-time":"2023-01-15T00:00:00Z","timestamp":1673740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Individuals with diabetic foot ulcers have overlapped the inflammatory, proliferative and remodeling phase, making the tissue vulnerable to delayed healing responses. We aimed to establish the dose\u2013response relationship of photobiomodulation therapy of different doses and matrix metalloproteinases in the healing dynamics of diabetic neuropathic ulcers. Diabetes was induced in 126 Albino Wistar rats, and neuropathy was induced to the hind paw by a sciatic nerve injury method. An excisional wound was created on the neuropathy\u2010induced leg. Photobiomodulation therapy of dosages 4, 6, 8, 10, 12 and 15\u2009J\u2009cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    and wavelength 655\u2009nm and 808\u2009nm was irradiated. Photobiomodulation therapy of dosages 4, 6 and 8\u2009J\u2009cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    showed better wound healing properties with optimized levels of matrix metalloproteinases\u20101 and 8. We observed a strong dose response in the experimental group treated with 6 and 8\u2009J\u2009cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    . The findings from the present study conclude that photobiomodulation therapy of dosages 4, 6 and 8\u2009J\u2009cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    is suggestive of usefulness in diabetic neuropathic ulcer healing. Markers like matrix metalloproteinases may give a clear direction on response to the therapy. Based on the findings from the present study, we recommend to validate the findings for safety and efficacy in future through human prospective randomized controlled clinical trials.\n                  <\/jats:p>","DOI":"10.1111\/php.13754","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T15:25:10Z","timestamp":1670426710000},"page":"1172-1180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dose\u2013Response Relationship of Photobiomodulation Therapy on Matrix Metalloproteinase in Healing Dynamics of Diabetic Neuropathic Ulcers\u2014An\n                    <i>in\u00a0vivo<\/i>\n                    Study"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1977-2716","authenticated-orcid":false,"given":"Gagana","family":"Karkada","sequence":"first","affiliation":[{"name":"Centre for Diabetic Foot Care and Research, Department of Physiotherapy Manipal College of Health Professions, Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3811-1350","authenticated-orcid":false,"given":"G Arun","family":"Maiya","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Manipal College of Health Professions, Chief\u2010Centre for Diabetic Foot Care and Research Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6116-2340","authenticated-orcid":false,"given":"Praveen","family":"Arany","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, School of Dental Medicine, Engineering &amp; Applied Sciences University at Buffalo  Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5832-0718","authenticated-orcid":false,"given":"Mohandas","family":"Rao KG","sequence":"additional","affiliation":[{"name":"Department of Anatomy Melaka Manipal Medical College\u2010Manipal, Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3369-194X","authenticated-orcid":false,"given":"Shalini","family":"Adiga","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Kasturba Medical College Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9896-0872","authenticated-orcid":false,"given":"Shobha U.","family":"Kamath","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Kasturba Medical College Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-3405-9"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2017.03.024"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734618791853"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1463-y"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2017.04.013"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.57606"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2897656"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201700370"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13757"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.13255"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.9734\/IJBCRR\/2016\/28222"},{"issue":"89","key":"e_1_2_12_13_1","article-title":"The sciatic nerve cuffing model of neuropathic pain in mice","volume":"16","author":"Yalcin I.","year":"2014","journal-title":"JoVE"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.96.4.0755"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2019.01.022"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2004.10.016"},{"key":"e_1_2_12_17_1","volume-title":"Principles & Techniques in Histology Microscopy and Photomicrography","author":"Singh D. 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