{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T09:05:27Z","timestamp":1769072727736,"version":"3.49.0"},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,15]],"date-time":"2023-01-15T00:00:00Z","timestamp":1673740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PD\/BD\/143129\/2019"],"award-info":[{"award-number":["PD\/BD\/143129\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/QUI\u2010OUT\/0303\/2021"],"award-info":[{"award-number":["PTDC\/QUI\u2010OUT\/0303\/2021"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/QUI\/00313\/2019"],"award-info":[{"award-number":["UID\/QUI\/00313\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Photodynamic therapy (PDT) remains an underutilized treatment modality in oncology. Many efforts have been dedicated to the development of better photosensitizers, better formulations and delivery methods, rigorous planning of light dose distribution in tissues, mechanistic insight, improvement of treatment protocols and combinations with other therapeutic agents. Hopefully, progress in all these fields will eventually expand the use of PDT. Here we offer a brief review of our own contribution to the development of a photosensitizer for PDT \u2013 redaporfin \u2013 currently in Phase II clinical trials, and present data on its combination with two glycolysis inhibitors: 2\u2010deoxyglucose and 3\u2010bromopyruvate. We show that 3\u2010bromopyruvate is more cytotoxic to a carcinoma cell line (CT26) than to a normal fibroblast (3T3) cell line, and that this selectivity is maintained in the <jats:italic>in\u00a0vitro<\/jats:italic> combination with redaporfin\u2010PDT. This combination was investigated in BALB\/c mice with large subcutaneous CT26 tumors and it is shown that the cure rate in the combination is higher (33% cures) than in PDT (11% cures) or in 3\u2010bromopyruvate (no cures) alone. The combination of redaporfin\u2010PDT with 3\u2010bromopyruvate illustrates the potential of combination therapies and how PDT benefits can be enhanced by systemic drugs with complementary targets.<\/jats:p>","DOI":"10.1111\/php.13770","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T06:49:02Z","timestamp":1671864542000},"page":"769-776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Redaporfin Development for Photodynamic Therapy and its Combination with Glycolysis Inhibitors<sup>\u2020<\/sup>"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0683-6717","authenticated-orcid":false,"given":"Maria In\u00eas P.","family":"Mendes","sequence":"first","affiliation":[{"name":"CQC\u2010IMS, Department of Chemistry University of Coimbra  Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3223-4819","authenticated-orcid":false,"given":"Luis G.","family":"Arnaut","sequence":"additional","affiliation":[{"name":"CQC\u2010IMS, Department of Chemistry University of Coimbra  Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.12.889"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20114"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5PP00132C"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2019.07.003"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1987.tb07898.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2007.00166.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.13253"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.13726"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/clm.1996.14.219"},{"key":"e_1_2_6_11_1","first-page":"1806","article-title":"Population pharmacokinetics of the photodynamic therapy agent 2\u2010[1\u2010Hexyloxyethyl]\u20102\u2010devinyl Pyropheophorbide\u2010a in cancer patients","volume":"63","author":"Bellnier D. A.","year":"2003","journal-title":"Cancer Res."},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(98)00015-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/cs9952400019"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(96)07421-0"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0104(02)00485-8"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385904-4.00006-8"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1351\/PAC-CON-12-08-16"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3765(19981102)4:11<2299::AID-CHEM2299>3.0.CO;2-H"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-6030(00)00382-8"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp013678p"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/1385272043370131"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201304202"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00052"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1142\/S1088424609000553"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2010.09.106"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201000524"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22931"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.12.027"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2md00308b"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201300449"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.06.002"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9010008"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000493423"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(01)00667-X"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2010.03.025"},{"key":"e_1_2_6_36_1","first-page":"1029","article-title":"The warburg effect and metabolic efficiency: Re\u2010crunching the numbers","volume":"324","author":"Koppenol W. H.","year":"2009","journal-title":"Science"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.5487\/TR.2016.32.3.177"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2008.01.003"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-012-9419-2"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-012-9422-7"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40170-021-00273-6"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2803"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20081258"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-008-9188-0"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.391"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4PP00288A"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-015-9604-1"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23020"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-021-01196-6"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c01350"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201500573"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c05844"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b07031"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.005280"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.113.206714"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.09.047"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-015-9612-1"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-012-9417-4"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah7192"}],"container-title":["Photochemistry and Photobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/php.13770","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/php.13770","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/php.13770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T17:49:58Z","timestamp":1692640198000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/php.13770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,15]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/php.13770"],"URL":"https:\/\/doi.org\/10.1111\/php.13770","archive":["Portico"],"relation":{},"ISSN":["0031-8655","1751-1097"],"issn-type":[{"value":"0031-8655","type":"print"},{"value":"1751-1097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,15]]},"assertion":[{"value":"2022-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}