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BL significantly inhibited the proliferation of B cell lymphoma (A20 and RAMOS) cells in a dose\u2010dependent manner. Anti\u2010proliferative effect of BL irradiation was identified to be associated with the inhibition of proliferating\u2010cell nuclear antigen expression and cell cycle by decreasing S\u2010phase cells. Consistent with its inhibitory effects, BL irradiation at 20\u2009J\/cm<jats:sup>2<\/jats:sup> daily for 10\u2009days inhibited metastasis of cancer cells which were distributed and invaded to other organs including bone marrow, liver, kidney, <jats:italic>etc.<\/jats:italic>, and induced paraplegia, thereby leading to an increased survival rate of tumor\u2010bearing mice. Anti\u2010proliferative activity of BL was expanded in solid tumor cells including pancreatic carcinoma (Mia PaCa\u20102, PANC\u20101), lung carcinoma A549 and colorectal carcinoma HCT116 cells. Additionally, combination with chemo\u2010drugs such as 5\u2010FU and gemcitabine resulted in an increase in the anti\u2010proliferative activity after BL irradiation accompanied by regulating mRNA translational process <jats:italic>via<\/jats:italic> inhibition of p70S6K, 4EBP\u20101 and eIF4E phosphorylation during cellular proliferation. These results indicate the anti\u2010metastatic and photo\u2010biogoverning abilities of BL irradiation as a potent therapeutic potential for repressing the progression of tumor cells.<\/jats:p>","DOI":"10.1111\/php.13789","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T05:45:39Z","timestamp":1675403139000},"page":"1438-1447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Blue Light Inhibits Proliferation of Metastatic Cancer Cells by Regulating Translational Initiation: A Synergistic Property with Anticancer Drugs"],"prefix":"10.1111","volume":"99","author":[{"given":"Phil\u2010Sun","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Molecular Imaging &amp; Therapeutic Medicine Research Center, Research Institute of Clinical Medicine of Jeonbuk National University\u2010Biomedical Research Institute of Jeonbuk National University Hospital Jeonbuk National University Medical School and Hospital  Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun\u2010Mi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Molecular Imaging &amp; Therapeutic Medicine Research Center, Research Institute of Clinical Medicine of Jeonbuk National University\u2010Biomedical Research Institute of Jeonbuk National University Hospital Jeonbuk National University Medical School and Hospital  Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima","family":"Boud","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Molecular Imaging &amp; Therapeutic Medicine Research Center, Research Institute of Clinical Medicine of Jeonbuk National University\u2010Biomedical Research Institute of Jeonbuk National University Hospital Jeonbuk National University Medical School and Hospital  Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SeokTae","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Molecular Imaging &amp; Therapeutic Medicine Research Center, Research Institute of Clinical Medicine of Jeonbuk National University\u2010Biomedical Research Institute of Jeonbuk National University Hospital Jeonbuk National University Medical School and Hospital  Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9539-342X","authenticated-orcid":false,"given":"Hwan\u2010Jeong","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Molecular Imaging &amp; Therapeutic Medicine Research Center, Research Institute of Clinical Medicine of Jeonbuk National University\u2010Biomedical Research Institute of Jeonbuk National University Hospital Jeonbuk National University Medical School and Hospital  Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/104454701753342758"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764170600607731"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2006.24.121"},{"key":"e_1_2_7_5_1","first-page":"320","article-title":"Effects of continuous\u2010wave (670\u2010nm) red light on wound healing","volume":"34","author":"Erdle B. 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