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It starts with premalignant lesions known as Intraepithelial Cervical Neoplasia (CIN) that can develop due to infection by Human Papillomavirus (HPV) and other microorganisms. Current CIN therapy involves invasive methods that affect cervix integrity and fertility; we propose the use of photodynamic therapy (PDT) as a strategy with few side effects. In this work, the effectiveness of PDT for CIN I, HPV and pathogenic vaginal microbiota elimination in 29 women of Mexico City with CIN I, CIN I\u2009+\u2009HPV and HPV diagnosis was determined. After 6\u2009months of PDT application, HPV infection was eliminated in 100% of the patients (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.01), CIN I\u2009+\u2009HPV in 64.3% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.01) and CIN I in 57.2% (<jats:italic>P<\/jats:italic>\u00a0&gt;\u20090.05). PDT also eliminated pathogenic microorganisms: <jats:italic>Chlamydia trachomatis<\/jats:italic> in 81% of the women (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001) and <jats:italic>Candida albicans<\/jats:italic> in 80% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.05), without affecting normal microbiota since <jats:italic>Lactobacillus iners<\/jats:italic> was eliminated only in 5.8% of patients and the opportunistic <jats:italic>Gardnerella vaginalis<\/jats:italic> in 20%. These results show that PDT was highly effective in eradicating HPV and pathogenic microorganisms, suggesting that PDT is a promising therapy for cervical infections.<\/jats:p>","DOI":"10.1111\/php.13791","type":"journal-article","created":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T17:49:10Z","timestamp":1676137750000},"page":"1468-1475","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Elimination of Human Papillomavirus and Cervical Pathological Microbiota with Photodynamic Therapy in Women from Mexico City with Cervical Intraepithelial Neoplasia I"],"prefix":"10.1111","volume":"99","author":[{"given":"Mar\u00eda Teresa","family":"L\u00f3pez\u2010C\u00e1rdenas","sequence":"first","affiliation":[{"name":"Laboratorio de Citopatolog\u00eda Ambiental, Departamento de Morfolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas Instituto Polit\u00e9cnico Nacional  Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Investigaci\u00f3n Hospital Ju\u00e1rez de M\u00e9xico  Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Araceli","family":"Espinosa\u2010Montesinos","sequence":"additional","affiliation":[{"name":"Cl\u00ednica de Displasias Hospital Regional \u201cGral. Ignacio Zaragoza\u201d ISSSTE  Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Maldonado\u2010Alvarado","sequence":"additional","affiliation":[{"name":"Laboratorio de Citopatolog\u00eda Ambiental, Departamento de Morfolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas Instituto Polit\u00e9cnico Nacional  Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha Olivia","family":"Osorio\u2010Peralta","sequence":"additional","affiliation":[{"name":"Laboratorio de Citolog\u00eda Exfoliativa Acapulco Guerrero  Acapulco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Martinez\u2010Escobar","sequence":"additional","affiliation":[{"name":"Laboratorio de Citopatolog\u00eda Ambiental, Departamento de Morfolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas Instituto Polit\u00e9cnico Nacional  Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Moreno\u2010V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Departamento de Patolog\u00eda, Hospital de Cardiolog\u00eda Centro M\u00e9dico Nacional Siglo XXI  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma. Guadalupe","family":"Aguilera\u2010Arreola","sequence":"additional","affiliation":[{"name":"Laboratorio de Bacteriolog\u00eda M\u00e9dica, Departamento de Microbiolog\u00eda Escuela Nacional de Ciencias Biol\u00f3gicas\u2010Instituto Polit\u00e9cnico Nacional  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2262-5207","authenticated-orcid":false,"given":"Eva","family":"Ram\u00f3n\u2010Gallegos","sequence":"additional","affiliation":[{"name":"Laboratorio de Citopatolog\u00eda Ambiental, Departamento de Morfolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas Instituto Polit\u00e9cnico Nacional  Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"World Health Organization.Cervical cancer Mexico 2021 country profile. 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