{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:43:10Z","timestamp":1791549790776,"version":"4.3.4"},"reference-count":80,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Exposure to ultraviolet radiation (UV\u2010R), from both natural and artificial tanning, heightens the risk of skin cancer by inducing molecular changes in cells and tissues. Despite established transcriptional alterations at a molecular level due to UV\u2010R exposure, uncertainties persist regarding UV radiation characterization and subsequent genomic changes. Our study aimed to mechanistically explore dose\u2010 and time\u2010dependent gene expression changes, that may drive short\u2010term (e.g., sunburn) and long\u2010term actinic (e.g., skin cancer) consequences. Using C57BL\/6N mouse skin, we analyzed transcriptomic expression following exposure to five erythemally weighted UV\u2010R doses (0, 5, 10, 20, and 40\u2009mJ\/cm<jats:sup>2<\/jats:sup>) emitted by a UV\u2010R tanning device. At 96\u2009h post\u2010exposure, 5\u2009mJ\/cm<jats:sup>2<\/jats:sup> induced 116 statistically significant differentially expressed genes (DEGs) associated with structural changes from UV\u2010R damage. The highest number of significant gene expression changes occurred at 6 and 48\u2009h post\u2010exposure in the 20 and 40\u2009mJ\/cm<jats:sup>2<\/jats:sup> dose groups. Notably, at 40\u2009mJ\/cm<jats:sup>2<\/jats:sup>, 13 DEGs related to skin barrier homeostasis were consistently perturbed across all timepoints. UV\u2010R exposure activated pathways involving oxidative stress, P53 signaling, inflammation, biotransformation, skin barrier maintenance, and innate immunity. This in\u00a0vivo study's transcriptional data offers mechanistic insights into both short\u2010term and potential non\u2010threshold\u2010dependent long\u2010term health effects of UV\u2010R tanning.<\/jats:p>","DOI":"10.1111\/php.13917","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T07:20:42Z","timestamp":1707290442000},"page":"1378-1398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Transcriptome analysis in mouse skin after exposure to ultraviolet radiation from a canopy sunbed"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1309-1752","authenticated-orcid":false,"given":"Sami S.","family":"Qutob","sequence":"first","affiliation":[{"name":"Consumer and Clinical Radiation Protection Bureau Health Canada  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha P. M.","family":"Roesch","sequence":"additional","affiliation":[{"name":"Consumer and Clinical Radiation Protection Bureau Health Canada  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandy","family":"Smiley","sequence":"additional","affiliation":[{"name":"Consumer and Clinical Radiation Protection Bureau Health Canada  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Bellier","sequence":"additional","affiliation":[{"name":"Consumer and Clinical Radiation Protection Bureau Health Canada  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Williams","sequence":"additional","affiliation":[{"name":"Environmental Health Science and Research Bureau Health Canada  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate B.","family":"Cook","sequence":"additional","affiliation":[{"name":"Environmental Health Science and Research Bureau Health Canada  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Meier","sequence":"additional","affiliation":[{"name":"Environmental Health Science and Research Bureau Health Canada  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Rowan\u2010Carroll","sequence":"additional","affiliation":[{"name":"Environmental Health Science and Research Bureau Health Canada  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole L.","family":"Yauk","sequence":"additional","affiliation":[{"name":"Department of Biology University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"McNamee","sequence":"additional","affiliation":[{"name":"Consumer and Clinical Radiation Protection Bureau Health Canada  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Canadian Cancer Society.Canadian Cancer Society's Advisory Committee on cancer statistics. Canadian Cancer Statistics. 2022. Accessed November 17 2023.www.cancer.ca\/Canadian\u2010Cancer\u2010Statistics\u20102022\u2010EN"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.24095\/hpcdp.35.S1.02"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2006.02.011"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2019.03.012"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2019.01.004"},{"key":"e_1_2_8_7_1","unstructured":"Scientific Committee on Health Environmental and Emerging Risks (SCHEER).Opinion on biological effects of ultraviolet radiation relevant to health with particular reference to sunbeds for cosmetic purposes. European Commission. 2016. Accessed November 17 2023.http:\/\/ec.europa.eu\/health\/scientific_committees\/scheer\/docs\/scheer_o_003.pdf"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2021.112892"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-56017-5_17"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140612222"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2005.00281.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2003.09.028"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206445"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/em.22196"},{"key":"e_1_2_8_15_1","unstructured":"International Organization for Standardization\/International Commission on Illumination.ISO\/CIE 17166:2019 Erythema reference action spectrum and standard erythema dose. 2019. Accessed April 14 2022.https:\/\/www.iso.org\/standard\/74167.html"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-010-0440-8"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfab009"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2022.105143"},{"key":"e_1_2_8_20_1","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu T","year":"2021","journal-title":"Innovation"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.21"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201404147"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00296.2014"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-018-0047-0"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2006.06.076"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1024"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70213-X"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/26.23.5288"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1129"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1353\/hpu.0.0257"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12777"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.173"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00731.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12984"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.92"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031293"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2019756118"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00712"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1615-3"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2020.06.014"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.01562"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.03.013"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00901"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-020-02395-0"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126486"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32444"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13084"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/cei\/uxac060"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-0882"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011957"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.70"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20174274"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1503491112"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-9-178"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1309576110"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8080807"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2006-7-8-232"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M511631200"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.4818"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12030862"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.729045"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.151.2.389"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100336200"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2011.02.006"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23683.x"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.19505.x"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.12.007"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34635"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2022.108413"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.19619.x"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2019.08.004"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/7866471"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1159\/000501732"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203167"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-019-03673-x"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2010.00764.x"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-022-01734-8"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200305032"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13133179"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.0554"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-2000"}],"container-title":["Photochemistry and Photobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/php.13917","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T13:30:11Z","timestamp":1727184611000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/php.13917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,5]]},"references-count":80,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/php.13917"],"URL":"https:\/\/doi.org\/10.1111\/php.13917","archive":["Portico"],"relation":{},"ISSN":["0031-8655","1751-1097"],"issn-type":[{"value":"0031-8655","type":"print"},{"value":"1751-1097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,5]]},"assertion":[{"value":"2023-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}