{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:40:15Z","timestamp":1785894015484,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In recent years, interest is growing in the biological cutaneous effects of high\u2010energy visible light (400\u2013450\u2009nm). In the present study, we explored the impact of blue light (BL) on the repair of pyrimidine dimers, the major class of premutagenic DNA damage induced by exposure to sunlight. We unambiguously demonstrate that the exposure of in\u00a0vitro reconstructed human epidermis to environmentally relevant doses of BL strongly decreases the rate of repair of cyclobutane pyrimidine dimers and pyrimidine (6\u20104) pyrimidone photoproducts induced by a subsequent UVB irradiation. Using the highly sensitive and specific liquid chromatography\u2010tandem mass spectrometry assay, we did not observe induction of pyrimidine dimers by BL alone. Finally, we showed that application, during the BL exposure step, of a formula containing a new filter, named TriAsorB and affording BL photoprotection, prevented the decrease in DNA repair efficiency. These results emphasize the potential deleterious effects of BL on DNA repair and the interest in providing adequate skin protection against this wavelength range of sunlight.<\/jats:p>","DOI":"10.1111\/php.13921","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T09:14:15Z","timestamp":1707815655000},"page":"1359-1364","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Blue light impairs the repair of UVB\u2010induced pyrimidine dimers in a human skin model"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5022-071X","authenticated-orcid":false,"given":"Thierry","family":"Douki","sequence":"first","affiliation":[{"name":"Univ. Grenoble Alpes CEA, CNRS, IRIG, SyMMES  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Bacqueville","sequence":"additional","affiliation":[{"name":"Dermo\u2010Cosm\u00e9tique et Personal Care Pierre Fabre Recherche &amp; D\u00e9veloppement  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Jacques","sequence":"additional","affiliation":[{"name":"Dermo\u2010Cosm\u00e9tique et Personal Care Pierre Fabre Recherche &amp; D\u00e9veloppement  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Geni\u00e8s","sequence":"additional","affiliation":[{"name":"Dermo\u2010Cosm\u00e9tique et Personal Care Pierre Fabre Recherche &amp; D\u00e9veloppement  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Roullet","sequence":"additional","affiliation":[{"name":"Dermo\u2010Cosm\u00e9tique et Personal Care Pierre Fabre Recherche &amp; D\u00e9veloppement  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Bessou\u2010Touya","sequence":"additional","affiliation":[{"name":"Dermo\u2010Cosm\u00e9tique et Personal Care Pierre Fabre Recherche &amp; D\u00e9veloppement  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Duplan","sequence":"additional","affiliation":[{"name":"Dermo\u2010Cosm\u00e9tique et Personal Care Pierre Fabre Recherche &amp; D\u00e9veloppement  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2023.112703"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.03.010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12718"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0281062"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9pp00425d"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000517644"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13854"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17242"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18196"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/18.4.811"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/18.12.2379"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotochemrev.2021.100403"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.57.030502.090938"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30738-6"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43630-021-00114-x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12150"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2015.06.015"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3pp25451h"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi034593c"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604213103"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-7992(85)80018-X"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12349031"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2005.05.001"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2008.01.005"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13492"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.255"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7401084"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2016.05.024"},{"key":"e_1_2_6_30_1","first-page":"243","article-title":"Sunscreen protection against UV\u2010induced pyrimidine dimers in DNA of human skin in\u00a0situ","volume":"5","author":"Freeman SE","year":"1988","journal-title":"Photo\u2010Dermatology"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/1011-1344(93)87107-X"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4TX00197D"},{"key":"e_1_2_6_33_1","first-page":"4128","article-title":"The efficacy of a broad\u2010spectrum sunscreen to protect engineered human skin from tissue and DNA damage induced by solar ultraviolet exposure","volume":"6","author":"Bissonauth V","year":"2000","journal-title":"Clin Cancer Res"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/b107894c"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2010.00834.x"}],"container-title":["Photochemistry and Photobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/php.13921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T13:28:45Z","timestamp":1727184525000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/php.13921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,13]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/php.13921"],"URL":"https:\/\/doi.org\/10.1111\/php.13921","archive":["Portico"],"relation":{},"ISSN":["0031-8655","1751-1097"],"issn-type":[{"value":"0031-8655","type":"print"},{"value":"1751-1097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,13]]},"assertion":[{"value":"2023-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}