{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:19:54Z","timestamp":1787015994148,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,3]],"date-time":"2024-03-03T00:00:00Z","timestamp":1709424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH\u201017\u20101\u20100226"],"award-info":[{"award-number":["W81XWH\u201017\u20101\u20100226"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mitochondria play an essential role in cancer treatment by providing apoptotic signals. Hexyl aminolevulinate, an FDA\u2010approved diagnosis for non\u2010muscle invasive bladder cancer, induces the production of protoporphyrin IX (PpIX) preferentially by mitochondria in cancer cells. Photosensitizer PpIX upon illumination can release active chemotherapy drugs from singlet oxygen\u2010activatable prodrugs. Prodrugs placed close enough to PpIX formed in mitochondria can improve the antitumor efficiency of PpIX\u2010PDT. The preferred uptake of prodrugs by cancer cells and tumors can further enhance the selective damage of cancer cells over non\u2010cancer cells and surrounding normal tissues. Mitochondriotropic prodrugs of anticancer drugs, such as paclitaxel and SN\u201038, were synthesized using rhodamine, a mitochondrial\u2010targeting moiety. In\u00a0vitro, the mitochondrial targeting helped achieve preferential cellular uptake in cancer cells. In RT112 cells (human bladder cancer cells), intracellular prodrug concentrations were 2\u20133 times higher than the intracellular prodrug concentrations in BdEC cells (human bladder epithelial cells), after 2\u2009h incubation. In an orthotopic rat bladder tumor model, mitochondria\u2010targeted prodrugs achieved as much as 34 times higher prodrug diffusion in the tumor area compared to the nontumor bladder area. Overall, mitochondria targeting made prodrugs more effective in targeting cancer cells and tumors over non\u2010tumor areas, thereby reducing nonspecific toxicity.<\/jats:p>","DOI":"10.1111\/php.13928","type":"journal-article","created":{"date-parts":[[2024,3,3]],"date-time":"2024-03-03T23:20:30Z","timestamp":1709508030000},"page":"1622-1635","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Mitochondrial targeting improves the selectivity of singlet\u2010oxygen cleavable prodrugs in\n                    <scp>NMIBC<\/scp>\n                    treatment"],"prefix":"10.1111","volume":"100","author":[{"given":"Kazi Md Mahabubur","family":"Rahman","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences University at Buffalo, The State University of New York  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh","family":"Bist","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University at Buffalo, The State University of New York  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soniya","family":"Kumbham","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University at Buffalo, The State University of New York  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.","family":"Foster","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Therapeutics Roswell Park Comprehensive Cancer Center  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukyung","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University at Buffalo, The State University of New York  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0835-464X","authenticated-orcid":false,"given":"Youngjae","family":"You","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University at Buffalo, The State University of New York  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/ITT.S202006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-013-1142-z"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eursup.2010.02.002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2013.01.009"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.64.1076"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.6_suppl.528"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euros.2022.04.015"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.13726"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.12.889"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)63021-0"},{"key":"e_1_2_8_13_1","unstructured":"Approval Package for: CYSVIEW for INTRAVESICAL SOLUTION 100 mg: CENTER FOR DRUG EVALUATION AND RESEARCH.https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2010\/022555Orig1s000Approv.pdf"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13291"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2019.03.053"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.13589"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","unstructured":"ForrestMD.Why Cancer Cells Have a more Hyperpolarised Mitochondrial Membrane Potential and Emergent Prospects for Therapy.2015.","DOI":"10.1101\/025197"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/wsbm.1595"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165808"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp051163i"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CC09994G"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/ml3003617"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600144"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.19.8.085007"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002280000151"},{"issue":"2","key":"e_1_2_8_26_1","first-page":"6227","article-title":"Blue light cystoscopy for detection and treatment of non\u2010muscle invasive bladder cancer","volume":"19","author":"Mark JR","year":"2012","journal-title":"Can J Urol"},{"key":"e_1_2_8_27_1","first-page":"1","article-title":"Preclinical evaluation of singlet oxygen\u2010cleavable prodrugs in combination with protoporphyrin IX\u2010photodynamic therapy in an orthotopic rat model of non\u2010muscle\u2010invasive bladder cancer\u2020","author":"Rahman KMM","year":"2023","journal-title":"Photochem Photobiol"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic201178e"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19598-2"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.2.990"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050082"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004240100703"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-022X(03)00032-0"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/50\/11\/011"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20114"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-015-9589-6"}],"container-title":["Photochemistry and Photobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/php.13928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T01:36:38Z","timestamp":1731720998000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/php.13928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,3]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/php.13928"],"URL":"https:\/\/doi.org\/10.1111\/php.13928","archive":["Portico"],"relation":{},"ISSN":["0031-8655","1751-1097"],"issn-type":[{"value":"0031-8655","type":"print"},{"value":"1751-1097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,3]]},"assertion":[{"value":"2023-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}