{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T08:24:55Z","timestamp":1785399895502,"version":"3.56.0"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["JCTD\u20102020\u201004"],"award-info":[{"award-number":["JCTD\u20102020\u201004"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32261133528"],"award-info":[{"award-number":["32261133528"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271921"],"award-info":[{"award-number":["82271921"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In recent years, studies have shown that low\u2010dose supplemental infrared (IR) irradiation exhibits systemic anti\u2010inflammatory effects. The gut microbiota is increasingly recognized as a potential mediator of these effects due to its role in regulating host metabolism and inflammatory responses. To investigate the role of gut microbiota diversity and metabolite changes in the mechanism of light\u2010emitting diodes (LED) infrared's anti\u2010inflammatory action, we conducted IR irradiation on mice. Serum inflammatory cytokines were measured using ELISA, and fecal samples were subjected to metagenomic, untargeted, and targeted metabolomic analyses. Our results demonstrated a significant increase in the anti\u2010inflammatory cytokine IL\u201010 in the IR group, accompanied by a declining trend in pro\u2010inflammatory cytokines. Gut microbiome analysis revealed distinct alterations in composition and functional genes between the groups, including the enrichment of beneficial bacteria like various species of <jats:italic>Parabacteroides<\/jats:italic> and <jats:italic>Akkermansia muciniphila<\/jats:italic> in the IR group. Notably, the IR group exhibited enrichment in carbohydrate metabolism pathways and a reduction in DNA damage and repair pathways. Furthermore, targeted metabolomic analysis highlighted a notable increase in short\u2010chain fatty acids (SCFAs), including butyric acid and isobutyric acid, which positively correlated with the abundance of several beneficial bacteria. These findings suggest a potential interplay between gut microbiota\u2010derived SCFAs and the anti\u2010inflammatory response. In conclusion, our study provides comprehensive insights into the changes in gut microbiota species and functions associated with IR irradiation. Moreover, we emphasize the significance of altered SCFAs levels in the IR group, which may contribute to the observed anti\u2010inflammatory effects. Our findings contribute valuable evidence supporting the role of low\u2010dose infrared light irradiation as an anti\u2010inflammatory therapy.<\/jats:p>","DOI":"10.1111\/php.14008","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T04:03:40Z","timestamp":1722398620000},"page":"458-470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Gut microbiota mediates the anti\u2010inflammatory effects of supplemental infrared irradiation in mice"],"prefix":"10.1111","volume":"101","author":[{"given":"Shijing","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering Beihang University  Beijing China"},{"name":"State Key Laboratory of Virtual Reality Technology and Systems, School of Computer Science and Engineering Beihang University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letian","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering Beihang University  Beijing China"},{"name":"State Key Laboratory of Virtual Reality Technology and Systems, School of Computer Science and Engineering Beihang University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Ma","sequence":"additional","affiliation":[{"name":"Research Center for Eco\u2010Environmental Sciences Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liting","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering Beihang University  Beijing China"},{"name":"State Key Laboratory of Virtual Reality Technology and Systems, School of Computer Science and Engineering Beihang University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueying","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering Beihang University  Beijing China"},{"name":"State Key Laboratory of Virtual Reality Technology and Systems, School of Computer Science and Engineering Beihang University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2116-5253","authenticated-orcid":false,"given":"Yuming","family":"Fu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering Beihang University  Beijing China"},{"name":"State Key Laboratory of Virtual Reality Technology and Systems, School of Computer Science and Engineering Beihang University  Beijing China"},{"name":"International Joint Research Center of Aerospace Biotechnology &amp; Medical Engineering Beihang University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering Beihang University  Beijing China"},{"name":"State Key Laboratory of Virtual Reality Technology and Systems, School of Computer Science and Engineering Beihang University  Beijing China"},{"name":"International Joint Research Center of Aerospace Biotechnology &amp; Medical Engineering Beihang University  Beijing China"},{"name":"Institute of Environmental Biology and Life Support Technology School of Biological Science and Medical Engineering, Beihang University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ejihpe12030024"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12282"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553002.2019.1625464"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.5978\/islsm.14-OR-08"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20516"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2005.020842"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3934\/biophy.2017.3.337"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.08.002"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i40.6141"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.121265"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-2083-z"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1882927"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.04.031"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.284091.116"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30114-4"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/photob.2021.0057"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2021.112156"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty560"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-019-1891-0"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061217"},{"key":"e_1_2_11_23_1","unstructured":"Vegan: community ecology package.2012."},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.2307\/1390807"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv033"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3176"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.65088"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-013-0500-6"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-559"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-985X.2010.00676_9.x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11010091"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10051020"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.00219"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/1043-2760(94)90105-8"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.9b03933"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322670"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05901-2"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2018.1517725"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-021-01065-2"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.01.015"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods11244113"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08530"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25815"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2012-13-9-r79"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14214475"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105420"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.820969"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2022.109364"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1386.033"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40104-022-00788-y"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-329213"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5b05350"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2021.02.023"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2021.08.001"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab951"}],"container-title":["Photochemistry and Photobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/php.14008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T03:19:08Z","timestamp":1742267948000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/php.14008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,30]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/php.14008"],"URL":"https:\/\/doi.org\/10.1111\/php.14008","archive":["Portico"],"relation":{},"ISSN":["0031-8655","1751-1097"],"issn-type":[{"value":"0031-8655","type":"print"},{"value":"1751-1097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,30]]},"assertion":[{"value":"2024-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}