{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:56:36Z","timestamp":1790808996107,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["2R44DE026083\u201003"],"award-info":[{"award-number":["2R44DE026083\u201003"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Photochem &amp; Photobiology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Superhydrophobic antimicrobial photodynamic therapy (SH\u2010aPDT) is advantageous wherein airborne singlet oxygen (<jats:sup>1<\/jats:sup>O<jats:sub>2<\/jats:sub>) is delivered from a device tip to kill a biofilm with no photosensitizer exposure and no bacterial selectivity (Gram + or Gram \u2212). For effective treatment of periodontitis, the frequency of treatment as well as the optical light fluence required is not known. Thus, we sought to determine whether single or repeated SH\u2010aPDT treatments would work best in\u00a0vivo using two fluence values: 60 and 125 J\/cm<jats:sup>2<\/jats:sup>. We assessed the efficacy of three protocols: single treatment; interval treatments (days 0, 2, and 7); and consecutive treatments (days 0, 1, and 2). After 30\u2009days of evaluation, we found that, SH\u2010aPDT in 3 consecutive treatments significantly decreased <jats:italic>Porphyromonas gingivalis<\/jats:italic> levels compared to single and interval SH\u2010aPDT treatments, as well as SRP\u2010chlorhexidine (CHX) controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Notably, clinical parameters also improved (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), and histological and stereometric analyses revealed that consecutive SH\u2010aPDT treatments were the most effective for promoting healing and reducing inflammation. Our study shows what works best for SH\u2010aPDT, while also demonstrating SH\u2010aPDT advantages to treatment of periodontitis including no bacterial selectivity (Gram + or Gram \u2212) and preventing the development of bacterial resistance.<\/jats:p>","DOI":"10.1111\/php.14021","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T12:45:57Z","timestamp":1728564357000},"page":"592-608","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of treatment frequency on the efficacy of superhydrophobic antimicrobial photodynamic therapy of periodontitis in a wistar rat model"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0058-9970","authenticated-orcid":false,"given":"Caroline","family":"Coradi Tonon","sequence":"first","affiliation":[{"name":"Wellman Center for Photomedicine Massachusetts General Hospital and Harvard Medical School  Boston 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